Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 19/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9914423 | 0.92 | ELANE (0.55) | ELANECYP2C9AR | |
| SCHEMBL8140858 | 0.88 | ELANE (0.61) | ELANECYP2C9 | |
| SCHEMBL9915268 | 0.85 | ELANE (0.53) | ELANECYP2C9 | |
| SCHEMBL1764340 | 0.83 | ELANE (0.60) | ELANECYP2C9 | |
| SCHEMBL1764175 | 0.81 | ELANE (0.74) | ELANECYP2C9 | |
| SCHEMBL3482663 | 0.79 | ELANE (0.72) | ELANECYP2C9 | |
| SCHEMBL14899941 | 0.78 | ELANE (0.71) | ELANECYP2C9 | |
| SCHEMBL1134182 | 0.77 | ELANE (0.52) | ELANECYP2C9AR | |
| SCHEMBL14796910 | 0.76 | ELANE (0.57) | ELANECYP2C9AR | |
| SCHEMBL9914425 | 0.76 | ELANE (0.53) | ELANECYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120202826-A1 | Tetrahydropyrrolopyrimidinediones And Their Use In Therapy | CHIESI FARMACEUTICI S.P.A. (IT) | 2012-08-09 | — | — | US | disclosed |
| US-8198288-B2 | Tetrahydropyrrolopyrimidinediones and their use in therapy | PULMAGEN THERAPEUTICS (INFLAMMATION) LIMITED (GB) | 2012-06-12 | — | — | US | disclosed |
| US-20090093477-A1 | TETRAHYDROPYRROLOPYRIMIDINEDIONES AND THEIR USE IN THERAPY | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202826-A1 | Tetrahydropyrrolopyrimidinediones And Their Use In Therapy | SERPINB1, ELANE, MPO | ELANE 2/4885CYP2C9 1646/4885AR 4671/4885 |
| US-20090093477-A1 | TETRAHYDROPYRROLOPYRIMIDINEDIONES AND THEIR USE IN THERAPY | NOX1, NOX3, ELANE | ELANE 3/4885CYP2C9 2216/4885AR 1525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.