Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 6/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.38 |
| ▸ | GABRR1 | P24046 | 5/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.38 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.38 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947066 | 0.82 | GABRA1 (0.41) | GABRA1GABRA5GABRB2GABRR1GABRA4 | |
| SCHEMBL13153726 | 0.79 | GABRA1 (0.44) | GABRA1GABRA5GABRB2GABRR1GABRA4 | |
| SCHEMBL10832322 | 0.68 | GABRA1 (0.61) | GABRA1GABRA5GABRB2GABRR1GABRA4 | |
| SCHEMBL9182927 | 0.67 | GABRA1 (0.45) | GABRA1GABRA5GABRB2GABRR1GABRA4 | |
| SCHEMBL17264265 | 0.67 | GABRA5 (0.45) | GABRA1GABRA5GABRB2GABRR1GABRA4 | |
| SCHEMBL19557235 | 0.67 | GABRA1 (0.45) | GABRA1GABRA5GABRB2GABRR1GABRA4 | |
| SCHEMBL10950450 | 0.67 | ALDH1A1 (0.43) | ALDH1A1MAPTGAALMNA | |
| SCHEMBL10950446 | 0.67 | ALDH1A1 (0.43) | ALDH1A1MAPTGAALMNA | |
| SCHEMBL25372380 | 0.63 | KDM4E (0.33) | ALDH1A1HPGDMAPTGAAMEN1 | |
| SCHEMBL364179 | 0.62 | ALDH1A1 (0.34) | ALDH1A1HPGDSMN1; SMN2MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |