Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 5/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | WDR5 | P61964 | 3/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9915363 | 0.88 | CYP1A2 (0.39) | S1PR3WDR5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16747529 | 0.88 | XDH (0.41) | XDHWDR5S1PR1ALDH1A1 | |
| SCHEMBL14124903 | 0.82 | XDH (0.54) | XDHKDM4EALDH1A1 | |
| SCHEMBL9915358 | 0.80 | S1PR3 (0.37) | XDHS1PR3WDR5PTPN11KDM4E | |
| SCHEMBL9915495 | 0.77 | SMPD1 (0.41) | S1PR3ALDH1A1 | |
| SCHEMBL14136596 | 0.77 | XDH (0.43) | XDHKDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL14124913 | 0.75 | XDH (0.43) | XDHALDH1A1 | |
| SCHEMBL9915473 | 0.72 | GAA (0.42) | XDHS1PR3WDR5 | |
| SCHEMBL9915354 | 0.72 | TP53 (0.33) | S1PR3 | |
| SCHEMBL16748705 | 0.70 | TP53 (0.37) | XDHS1PR3WDR5PTPN11KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120302542-A1 | MONOBACTAMS | PFIZER INC | 2012-11-29 | — | — | US | disclosed |
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120302542-A1 | MONOBACTAMS | MGAM, MGAM2, BPGM | XDH 2263/4885S1PR3 3452/4885WDR5 1512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.