Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 4/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15275358 | 0.86 | MAPT (0.54) | MAPTSMN1; SMN2RECQLCYP1A2CYP2C19 | |
| SCHEMBL9915307 | 0.78 | RAB9A (0.43) | MAPTSMN1; SMN2HPGDTSHRRAB9A | |
| SCHEMBL9915431 | 0.78 | NOTUM (0.36) | CYP1A2CYP2C19CA12CA9CYP19A1 | |
| SCHEMBL9915473 | 0.72 | GAA (0.42) | TSHR | |
| SCHEMBL9915470 | 0.71 | SMPD1 (0.37) | MAPTSMN1; SMN2HTTTSHR | |
| SCHEMBL15279029 | 0.70 | KMT2A (0.41) | MAPTSMN1; SMN2HPGDTSHRRAB9A | |
| SCHEMBL9915312 | 0.68 | ALDH1A1 (0.47) | MAPTSMN1; SMN2RECQLHPGDTSHR | |
| SCHEMBL14124959 | 0.66 | NOTUM (0.46) | SMN1; SMN2STAT3HPGDRAB9ANPC1 | |
| SCHEMBL9915495 | 0.65 | SMPD1 (0.41) | MAPTRECQLHTTHPGDALDH1A1 | |
| SCHEMBL1457566 | 0.65 | MAPT (0.63) | MAPTSMN1; SMN2RECQLCYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646436-B1 | MONOBACTAMS | PFIZER (US) | 2015-05-27 | — | — | EP | disclosed |
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |