Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9915507 | 0.88 | GAA (0.46) | SMPD1TP53TSHRSMN1; SMN2SGPL1 | |
| SCHEMBL14124863 | 0.81 | LMNA (0.44) | SMPD1MAPTSMN1; SMN2TDP1NPC1 | |
| SCHEMBL16748640 | 0.80 | SMPD1 (0.38) | SMPD1TP53TSHRMAPTSMN1; SMN2 | |
| SCHEMBL9915470 | 0.78 | SMPD1 (0.37) | SMPD1TP53TSHRMAPTSMN1; SMN2 | |
| SCHEMBL9915474 | 0.77 | MAPT (0.41) | SMPD1TP53TSHRMAPTSMN1; SMN2 | |
| SCHEMBL12334447 | 0.76 | SMPD1 (0.64) | SMPD1TP53TSHRSMN1; SMN2ALPL | |
| SCHEMBL9915361 | 0.74 | ALPL (0.37) | SMPD1TP53TSHRMAPTSMN1; SMN2 | |
| SCHEMBL9915483 | 0.72 | MAPT (0.47) | SMPD1TP53TSHRMAPT | |
| SCHEMBL16748641 | 0.69 | GAA (0.43) | SMPD1TP53TSHRSGPL1TDP1 | |
| SCHEMBL5283038 | 0.69 | PPARA (0.46) | SMPD1TP53MAPTSMN1; SMN2ALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148326-A1 | Monobactams | PFIZER (US) | 2015-05-28 | — | — | US | disclosed |
| EP-2646436-B1 | MONOBACTAMS | PFIZER (US) | 2015-05-27 | — | — | EP | disclosed |
| US-20130252935-A1 | Monobactams | PFIZER INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20120302542-A1 | MONOBACTAMS | PFIZER INC | 2012-11-29 | — | — | US | disclosed |
| WO-2012073138-A1 | MONOBACTAMS | PFIZER INC. (US) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252935-A1 | Monobactams | MGAM, MGAM2, BPGM | SMPD1 2714/4885TP53 4737/4885TSHR 4478/4885 |
| US-20150148326-A1 | Monobactams | MGAM, MGAM2, BPGM | SMPD1 2714/4885TP53 4737/4885TSHR 4478/4885 |
| US-20120302542-A1 | MONOBACTAMS | MGAM, MGAM2, BPGM | SMPD1 2714/4885TP53 4737/4885TSHR 4478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.