Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.42 |
| ▸ | CTSA | P10619 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 2/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL951351 | 0.80 | KDM4E (0.43) | CTSARAB9A | |
| SCHEMBL2492927 | 0.77 | KMO (0.44) | MRGPRX4NPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL2489148 | 0.76 | PPARD (0.43) | MRGPRX4PTGER1CTSANPC1POLB | |
| SCHEMBL2490382 | 0.74 | KDM4E (0.43) | MRGPRX4PTGER1CTSAPPARD | |
| SCHEMBL934656 | 0.73 | CTSA (0.44) | CTSA | |
| SCHEMBL2491639 | 0.73 | MCL1 (0.43) | MRGPRX4PTGER1 | |
| SCHEMBL999406 | 0.73 | NPC1 (0.52) | PTGER1NPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL4038711 | 0.71 | FFAR1 (0.42) | MRGPRX4NPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL2492027 | 0.71 | CSNK2A2 (0.41) | MRGPRX4NPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL2488886 | 0.70 | CSNK2A2 (0.39) | MRGPRX4CTSANPC1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011007091-A1 | DERIVATIVES OF 5,6-BISARYL-2-PYRIDINE-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF AS UROTENSIN-II RECEPTOR ANTAGONISTS | SANOFI-AVENTIS (FR) | 2011-01-20 | — | — | WO | disclosed |