Nonivamide

Nonivamide

SCHEMBL992015

CCCCCCCCC(=O)NCc1ccc(O)c(OC)c1.COc1cc(CNC(=S)NCc2ccc(C(C)(C)C)cc2)ccc1O

nearest known ligand 0.75

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.75
CYP3A4 P08684 2/20 0.75
CYP2D6 P10635 2/20 0.75
HPGD P15428 2/20 0.75
ALDH1A1 P00352 1/20 0.75
CYP2C9 P11712 1/20 0.75
ALOX15 P16050 1/20 0.75
CYP2C19 P33261 1/20 0.75
BLM P54132 1/20 0.75
PMP22 Q01453 1/20 0.75
TRPV1 Q8NER1 5/20 0.71
MEN1 O00255 1/20 0.67
TP53 P04637 1/20 0.67
MAPT P10636 1/20 0.67
MTOR P42345 1/20 0.67
KMT2A Q03164 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29371389 0.87 CYP1A2 (1.00) CYP1A2CYP3A4CYP2D6HPGDALDH1A1
SCHEMBL5889449 0.87 CYP1A2 (1.00) CYP1A2CYP3A4CYP2D6HPGDALDH1A1
SCHEMBL1155582 0.87 CYP1A2 (1.00) CYP1A2CYP3A4CYP2D6HPGDALDH1A1
SCHEMBL5088067 0.87 CYP1A2 (1.00) CYP1A2CYP3A4CYP2D6HPGDALDH1A1
SCHEMBL8373082 0.87 CYP1A2 (1.00) CYP1A2CYP3A4CYP2D6HPGDALDH1A1
SCHEMBL679954 0.87 CYP1A2 (1.00) CYP1A2CYP3A4CYP2D6HPGDALDH1A1
Nonivamide SCHEMBL81939 0.87 CYP1A2 (1.00) CYP1A2CYP3A4CYP2D6HPGDALDH1A1
SCHEMBL2400979 0.87 CYP1A2 (1.00) CYP1A2CYP3A4CYP2D6HPGDALDH1A1
SCHEMBL1155739 0.87 CYP1A2 (1.00) CYP1A2CYP3A4CYP2D6HPGDALDH1A1
Nonivamide SCHEMBL29425552 0.87 CYP1A2 (1.00) CYP1A2CYP3A4CYP2D6HPGDALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220227774-A1 P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS ASANA BIOSCIENCES, LLC 2022-07-21 US disclosed
US-11339169-B2 P2X3 and/or P2X2/3 compounds and methods ASANA BIOSCIENCES, LLC (US) 2022-05-24 US disclosed
EP-3083619-B1 P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS ASANA BIOSCIENCES LLC (US) 2021-11-03 EP disclosed
EP-3363437-B1 AMINOINDANE COMPOUNDS AND USE THEREOF IN TREATING PAIN ENDO PHARMACEUTICALS SOLUTIONS (US) 2021-07-28 EP disclosed
US-20200190096-A1 P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS ASANA BIOSCIENCES, LLC 2020-06-18 US disclosed
US-10611768-B2 P2X3 and/or P2X2/3 compounds and methods ASANA BIOSCIENCES, LLC (US) 2020-04-07 US disclosed
US-10590127-B2 P2X3 and/or P2X2/3 compounds and methods ASANA BIOSCIENCES, LLC (US) 2020-03-17 US disclosed
US-10544145-B2 P2X3 and/or P2X2/3 compounds and methods ASANA BIOSCIENCES, LLC (US) 2020-01-28 US disclosed
EP-3528813-A1 P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS Asana BioSciences, LLC (US) 2019-08-28 EP disclosed
US-20190248789-A1 P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS ABS DEVELOPMENT 1, INC. 2019-08-15 US disclosed
US-20140213552-A1 CYCLOHEXYLAMINES ENDO PHARMACEUTICALS INC. (US) 2014-07-31 US disclosed
WO-2014028675-A1 USE OF AMINOINDANE COMPOUNDS IN TREATING OVERACTIVE BLADDER AND INTERSTITIAL CYSTITIS ENDO PHARMACEUTICALS INC. (US) 2014-02-20 WO disclosed
EP-2675787-A1 AMINOINDANE COMPOUNDS AND USE THEREOF IN TREATING PAIN Endo Pharmaceuticals Inc. (US) 2013-12-25 EP disclosed
WO-2013063127-A1 CYCLOHEXYLAMINES ENDO PHARMACEUTICALS INC. (US) 2013-05-02 WO disclosed
US-20130101667-A1 Cyclohexylamines ENDO PHARMACEUTICALS, INC. (US) 2013-04-25 US disclosed
WO-2012112969-A1 AMINOINDANE COMPOUNDS AND USE THEREOF IN TREATING PAIN ENDO PHARMACEUTICALS INC. (US) 2012-08-23 WO disclosed
US-20120214809-A1 Aminoindane Compounds and Use Thereof in Treating Pain Libertas Bio, Inc. 2012-08-23 US disclosed
US-20110086818-A1 METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITUS PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) 2011-04-14 US disclosed
EP-2271329-A2 METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS President and Fellows of Harvard College (US) 2011-01-12 EP disclosed
WO-2009114139-A2 METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2009-09-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10544145-B2 P2X3 and/or P2X2/3 compounds and methods P2RX3, P2RX2, P2RX1 CYP1A2 1920/4885CYP3A4 2422/4885CYP2D6 1713/4885
US-20220227774-A1 P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS P2RX3, P2RX6, P2RX2 CYP1A2 1779/4885CYP3A4 2455/4885CYP2D6 1132/4885
US-11339169-B2 P2X3 and/or P2X2/3 compounds and methods P2RX3, P2RX6, P2RX2 CYP1A2 1779/4885CYP3A4 2455/4885CYP2D6 1132/4885
US-20120214809-A1 Aminoindane Compounds and Use Thereof in Treating Pain TRPA1, TRPV1, TRPV2 CYP1A2 1238/4885CYP3A4 3017/4885CYP2D6 1509/4885
US-20200190096-A1 P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS P2RX3, P2RX6, P2RX2 CYP1A2 1779/4885CYP3A4 2455/4885CYP2D6 1132/4885
US-10590127-B2 P2X3 and/or P2X2/3 compounds and methods P2RX3, P2RX2, P2RX1 CYP1A2 1695/4885CYP3A4 2035/4885CYP2D6 1635/4885
US-20110086818-A1 METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITUS TRPV1, OPRL1, ITCH CYP1A2 4784/4885CYP3A4 4788/4885CYP2D6 4656/4885
US-10611768-B2 P2X3 and/or P2X2/3 compounds and methods P2RX3, P2RX6, P2RX2 CYP1A2 1779/4885CYP3A4 2455/4885CYP2D6 1132/4885
US-20140213552-A1 CYCLOHEXYLAMINES TRPV1, TRPA1, OPRL1 CYP1A2 1217/4885CYP3A4 2668/4885CYP2D6 1398/4885
US-20130101667-A1 Cyclohexylamines TRPV1, TRPA1, OPRL1 CYP1A2 1217/4885CYP3A4 2668/4885CYP2D6 1398/4885
US-20190248789-A1 P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS P2RX3, P2RX2, P2RX1 CYP1A2 1920/4885CYP3A4 2422/4885CYP2D6 1713/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.