Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.33 |
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | FES | P07332 | 1/20 | 0.33 |
| ▸ | ROS1 | P08922 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9923471 | 0.77 | CAMKK2 (0.38) | MAP4K1JAK2JAK3CLK4 | |
| SCHEMBL9923305 | 0.75 | AXL (0.43) | JAK2JAK3 | |
| SCHEMBL15155054 | 0.75 | GSK3B (0.35) | MAP4K1ROCK2GSK3BNTRK1ROCK1 | |
| SCHEMBL2600520 | 0.68 | AKT1 (0.38) | ROCK2IRAK4ROCK1CDC42BPBKHK | |
| SCHEMBL2600517 | 0.68 | ROCK2 (0.35) | ROCK2IRAK4ROCK1CDC42BPBKHK | |
| SCHEMBL9923364 | 0.67 | PRKCI (0.57) | JAK2JAK3GSK3BNTRK1AURKA | |
| SCHEMBL24420608 | 0.65 | KDM4E (0.35) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| SCHEMBL9923368 | 0.64 | CAMKK2 (0.39) | JAK2JAK3CLK4 | |
| SCHEMBL2600508 | 0.64 | ROCK2 (0.39) | MAP4K1ROCK2IRAK4ROCK1CDC42BPB | |
| SCHEMBL1468379 | 0.63 | GSK3B (0.37) | ROCK2GSK3BDYRK1AIRAK4ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012078802-A1 | PREPARATION OF SUBSTITUTED-4,5-DIHYDROPYRROLO[4,3,2-de][2,6]NAPHTHYRIDIN-3(1H)-ONES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-06-14 | — | — | WO | disclosed |