Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9923858 | 0.94 | ALDH1A1 (0.41) | CHRM1MCHR1SMN1; SMN2LMNAHTT | |
| SCHEMBL9924065 | 0.91 | P2RX7 (0.42) | — | |
| SCHEMBL9924274 | 0.91 | CHRM1 (0.41) | CHRM1ROCK2ROCK1MCHR1CYP2C9 | |
| SCHEMBL9924066 | 0.88 | CHRM1 (0.41) | CHRM1MCHR1SMN1; SMN2LMNAHTT | |
| SCHEMBL9923856 | 0.88 | CHRM1 (0.42) | CHRM1ROCK2ROCK1MCHR1SMN1; SMN2 | |
| SCHEMBL9923860 | 0.88 | P2RX7 (0.40) | CHRM1MCHR1SMN1; SMN2LMNACYP2C9 | |
| SCHEMBL9923857 | 0.88 | LMNA (0.40) | CHRM1ROCK2ROCK1SMN1; SMN2LMNA | |
| SCHEMBL9924064 | 0.88 | CHRM1 (0.40) | CHRM1ROCK2ROCK1MCHR1SMN1; SMN2 | |
| SCHEMBL9924156 | 0.87 | CHRM1 (0.45) | CHRM1MCHR1CYP2C9MAPK14ALDH1A1 | |
| SCHEMBL9924270 | 0.87 | HPGD (0.40) | CHRM1MCHR1SMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169199-B2 | Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2015-10-27 | — | — | US | disclosed |
| WO-2012078867-A2 | CYCLOALKYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORPORATION (US) | 2012-06-14 | — | — | WO | disclosed |