Sugi Predict

Sugi Predict / Compounds / SCHEMBL9924039

SCHEMBL9924039

SCHEMBL9924039

Cc1c(NC(=O)OC(C)(C)C)nc2ccc(Cl)cn12

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.44
▸ GAA P10253 4/20 0.44
▸ POLB P06746 1/20 0.44
▸ EIF2AK4 Q9P2K8 2/20 0.39
▸ CYP1A2 P05177 2/20 0.39
▸ CYP2C9 P11712 2/20 0.39
▸ CYP2C19 P33261 2/20 0.39
▸ ALOX5 P09917 1/20 0.39
▸ MAPT P10636 3/20 0.39
▸ KMT2A Q03164 2/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ CYP2D6 P10635 1/20 0.38
▸ HPGD P15428 1/20 0.38
▸ MAP3K5 Q99683 1/20 0.38
▸ LCK P06239 1/20 0.38
▸ ATR Q13535 1/20 0.38
▸ KDM4E B2RXH2 2/20 0.37
▸ LMNA P02545 1/20 0.37
▸ TP53 P04637 1/20 0.37
▸ MAPK1 P28482 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9923990 0.87 KDM4E (0.44) ALDH1A1POLBMAPTKMT2AHPGD
SCHEMBL15631803 0.85 CYP11B1 (0.44) ALDH1A1MAP3K5KDM4ESMN1; SMN2ABL1
SCHEMBL9942081 0.83 MCHR1 (0.41) POLBEIF2AK4LMNAABL1LRRK2
SCHEMBL9893317 0.83 ALDH1A1 (0.51) ALDH1A1GAAPOLBCYP1A2CYP2C9
SCHEMBL22519299 0.82 ALDH1A1 (0.40) ALDH1A1GAAPOLBEIF2AK4CYP1A2
SCHEMBL9923913 0.80 KDM4E (0.43) ALDH1A1POLBMAPTHPGDMAP3K5
SCHEMBL9923873 0.80 ALDH1A1 (0.48) ALDH1A1GAAKMT2AHPGDKDM4E
SCHEMBL9924052 0.76 KDM4E (0.45) ALDH1A1GAACYP1A2CYP2C9CYP2C19
SCHEMBL15631825 0.75 TRPA1 (0.42) ALDH1A1POLBEIF2AK4MAPTHPGD
SCHEMBL15690014 0.73 BRD9 (0.38) LCKATRPTGDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9067935-B2 Imidazo[1,2-α]pyridine sulfonamides as TRPM8 modulators JANSSEN PHARMACEUTICA, NV (BE) 2015-06-30 — — US disclosed
US-9067935-B2 Imidazo[1,2-α]pyridine sulfonamides as TRPM8 modulators JANSSEN PHARMACEUTICA, NV (BE) 2015-06-30 — — US disclosed
US-20140088098-A1 IMIDAZO[1,2-a]PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS JANSSEN PHARMACEUTICA, NV (BE) 2014-03-27 — — US disclosed
US-20140088098-A1 IMIDAZO[1,2-a]PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS JANSSEN PHARMACEUTICA, NV (BE) 2014-03-27 — — US disclosed
US-20120149699-A1 IMIDAZO[1,2-a]PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS JANSSEN PHARMACEUTICA, NV (BE) 2012-06-14 — — US disclosed
WO-2012078994-A1 IMIDAZO [1, 2-A] PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2012-06-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120149699-A1 IMIDAZO[1,2-a]PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS TRPM8, TRPV1, TRPM2 ALDH1A1 2230/4885GAA 2699/4885POLB 4591/4885
US-20140088098-A1 IMIDAZO[1,2-a]PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS TRPM8, TRPV1, TRPM2 ALDH1A1 2230/4885GAA 2699/4885POLB 4591/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.