Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | DCUN1D1 | Q96GG9 | 9/20 | 0.45 |
| ▸ | UBE2M | P61081 | 8/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | IDH2 | P48735 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17206695 | 0.91 | EPHX2 (0.46) | SMN1; SMN2DCUN1D1UBE2MMEN1KMT2A | |
| SCHEMBL9924424 | 0.89 | TRPV1 (0.45) | MAPTHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL9924275 | 0.87 | THRB (0.45) | MAPTHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL17206619 | 0.87 | EPHX2 (0.48) | MAPTHTTDCUN1D1UBE2MMEN1 | |
| SCHEMBL9924133 | 0.86 | EPHX2 (0.47) | MAPTHTTDCUN1D1UBE2MMEN1 | |
| SCHEMBL17206718 | 0.85 | UBE2M (0.43) | MAPTHTTSMN1; SMN2DCUN1D1UBE2M | |
| SCHEMBL17206682 | 0.84 | TRPV4 (0.48) | MAPTHTTDCUN1D1UBE2MMEN1 | |
| SCHEMBL9924156 | 0.84 | CHRM1 (0.45) | — | |
| SCHEMBL17206685 | 0.84 | MEN1 (0.49) | MAPTHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL9924143 | 0.82 | EPHX2 (0.44) | DCUN1D1UBE2MMEN1KMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169199-B2 | Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2015-10-27 | — | — | US | disclosed |
| WO-2012078867-A2 | CYCLOALKYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORPORATION (US) | 2012-06-14 | — | — | WO | disclosed |