Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LHCGR | P22888 | 1/20 | 0.39 |
| ▸ | RAPGEF3 | O95398 | 2/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MC5R | P33032 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.35 |
| ▸ | RHOC | P08134 | 2/20 | 0.35 |
| ▸ | RHOA | P61586 | 2/20 | 0.35 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 2/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9924261 | 0.90 | TRPV1 (0.42) | LHCGRRAPGEF3RAPGEF4GRM4CYP2D6 | |
| SCHEMBL17206704 | 0.84 | CYP2D6 (0.37) | LHCGRRAPGEF3RAPGEF4CYP2D6EPHX2 | |
| SCHEMBL9924081 | 0.82 | TRPV1 (0.44) | RAPGEF3RAPGEF4GRM4CYP2D6SLC6A9 | |
| SCHEMBL9924438 | 0.82 | TRPV1 (0.44) | RAPGEF3RAPGEF4GRM4CYP2D6SLC6A9 | |
| SCHEMBL9924215 | 0.80 | SLC6A9 (0.41) | GRM4CYP2D6MC5REPHX2ALDH1A1 | |
| SCHEMBL9924333 | 0.79 | NPC1 (0.44) | GRM4MC5RCCR3CRHR1 | |
| SCHEMBL9924083 | 0.79 | NPC1 (0.44) | GRM4MC5RCCR3CRHR1 | |
| SCHEMBL17206736 | 0.78 | GRM4 (0.38) | LHCGRRAPGEF3RAPGEF4GRM4CYP2D6 | |
| SCHEMBL9924090 | 0.78 | APOB (0.40) | RAPGEF3RAPGEF4GRM4MC5REPHX2 | |
| SCHEMBL9924450 | 0.77 | NPC1 (0.47) | GRM4MC5REPHX2ALDH1A1SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169199-B2 | Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2015-10-27 | — | — | US | disclosed |
| US-9169199-B2 | Cycloalkyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2015-10-27 | — | — | US | disclosed |
| WO-2012078867-A2 | CYCLOALKYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORPORATION (US) | 2012-06-14 | — | — | WO | disclosed |