Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 4/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SI | P14410 | 1/20 | 0.31 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21811674 | 0.83 | ALDH1A1 (0.45) | ALDH1A1TRPA1MAPTCYP2C19L3MBTL1 | |
| SCHEMBL9239313 | 0.82 | MGAM (0.50) | ALDH1A1MAPTCYP3A4TSHRATM | |
| SCHEMBL5859548 | 0.82 | MGAM (0.50) | ALDH1A1MAPTCYP3A4TSHRATM | |
| SCHEMBL14672451 | 0.82 | MAPT (0.47) | ALDH1A1MAPTCYP3A4TSHRATM | |
| SCHEMBL2854978 | 0.82 | MAPT (0.47) | ALDH1A1MAPTCYP2C19CYP3A4TSHR | |
| SCHEMBL30320231 | 0.82 | MAPT (0.47) | ALDH1A1MAPTCYP2C19CYP3A4TSHR | |
| SCHEMBL537525 | 0.79 | — | — | |
| SCHEMBL9925375 | 0.78 | MAPT (0.44) | ALDH1A1MAPTL3MBTL1CYP3A4TSHR | |
| SCHEMBL9925376 | 0.78 | MAPT (0.44) | ALDH1A1MAPTCYP3A4TSHRATM | |
| SCHEMBL491526 | 0.78 | MAPT (0.53) | ALDH1A1MAPTCYP3A4TSHRATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8754067-B2 | 22-haloacetoxy-homopregnacalciferol analogs and their uses | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2014-06-17 | — | — | US | disclosed |
| US-8754067-B2 | 22-haloacetoxy-homopregnacalciferol analogs and their uses | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2014-06-17 | — | — | US | disclosed |
| US-20120149669-A1 | 22-Haloacetoxy-Homopregnacalciferol Analogs and Their Uses | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-06-14 | — | — | US | disclosed |
| US-20120149669-A1 | 22-Haloacetoxy-Homopregnacalciferol Analogs and Their Uses | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149669-A1 | 22-Haloacetoxy-Homopregnacalciferol Analogs and Their Uses | CYP27B1, CYP27A1, MCL1 | ALDH1A1 769/4885TRPA1 3372/4885MAPT 4346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.