Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 11/20 | 0.67 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | HPN | P05981 | 1/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.61 |
| ▸ | DRD2 | P14416 | 1/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.61 |
| ▸ | CNR1 | P21554 | 1/20 | 0.61 |
| ▸ | DRD1 | P21728 | 1/20 | 0.61 |
| ▸ | DRD4 | P21917 | 1/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL84149 | 0.92 | OPRD1 (0.72) | OPRD1OPRM1OPRK1KCNH2MEN1 | |
| SCHEMBL9925787 | 0.92 | OPRD1 (0.72) | OPRD1OPRM1OPRK1KCNH2MEN1 | |
| SCHEMBL9925785 | 0.91 | OPRD1 (0.65) | OPRD1OPRM1OPRK1KCNH2CYP3A4 | |
| SCHEMBL9925788 | 0.91 | OPRD1 (0.65) | OPRD1OPRM1OPRK1KCNH2CYP3A4 | |
| SCHEMBL231375 | 0.90 | OPRD1 (0.67) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL15764535 | 0.90 | OPRD1 (0.67) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL4825406 | 0.90 | OPRD1 (0.67) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL84143 | 0.89 | OPRD1 (0.66) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL12569760 | 0.89 | OPRD1 (0.66) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL14108184 | 0.89 | OPRD1 (0.66) | OPRD1OPRM1OPRK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149717-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | BROWN WILLIAM (CA) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149717-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | OPRM1, OPRL1, PNMT | OPRD1 8/4885OPRM1 1/4885OPRK1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.