Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 15/20 | 0.66 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.63 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12569760 | 1.00 | OPRD1 (0.66) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL73453 | 0.92 | OPRD1 (0.71) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL71181 | 0.92 | OPRD1 (0.71) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL71180 | 0.92 | OPRD1 (0.71) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL29457724 | 0.92 | OPRD1 (0.71) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL72775 | 0.91 | OPRD1 (0.64) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL72787 | 0.91 | OPRD1 (0.64) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL4825427 | 0.90 | OPRD1 (0.65) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL15764535 | 0.89 | OPRD1 (0.67) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL231375 | 0.89 | OPRD1 (0.67) | OPRD1OPRM1OPRK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7915413-B2 | Compounds | ASTRAZENECA AB (SE) | 2011-03-29 | — | — | US | claimed |
| US-20110039858-A1 | Novel Compounds | ASTRAZENECA AB (SE) | 2011-02-17 | — | — | US | claimed |
| EP-1395567-B1 | 4 (PHENYL-PIPERAZINYL-METHYL) BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN ANXIETY OR GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2009-01-14 | — | — | EP | claimed |
| US-20070270435-A1 | Novel Compounds | ASTRAZENECA AB (SE) | 2007-11-22 | — | — | US | claimed |
| US-7229994-B2 | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2007-06-12 | — | — | US | claimed |
| US-20040147526-A1 | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2004-07-29 | — | — | US | claimed |
| EP-1395567-A1 | 4 (PHENYL-PIPERAZINYL-METHYL) BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN ANXIETY OR GASTROINTESTINAL DISORDERS | AstraZeneca AB (SE) | 2004-03-10 | — | — | EP | claimed |
| WO-2002094794-A1 | 4 (PHENYL-PIPERAZINYL-METHYL) BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN ANXIETY OR GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2002-11-28 | — | — | WO | claimed |
| US-20120149717-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | BROWN WILLIAM (CA) | 2012-06-14 | — | — | US | disclosed |
| US-20120149717-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | BROWN WILLIAM (CA) | 2012-06-14 | — | — | US | disclosed |
| US-8129393-B2 | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof | ASTRAZENECA AB (SE) | 2012-03-06 | — | — | US | disclosed |
| US-8129393-B2 | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof | ASTRAZENECA AB (SE) | 2012-03-06 | — | — | US | disclosed |
| US-8022074-B2 | 4-(phenyl-piperazinyl-methyl)benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2011-09-20 | — | — | US | disclosed |
| US-8022074-B2 | 4-(phenyl-piperazinyl-methyl)benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2011-09-20 | — | — | US | disclosed |
| US-7229994-B2 | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2007-06-12 | — | — | US | disclosed |
| US-7229994-B2 | 4(phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2007-06-12 | — | — | US | disclosed |
| US-20060122193-A1 | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2006-06-08 | — | — | US | disclosed |
| EP-1562924-A1 | 4(PHENYL-PIPERAZINYL-METHYL) BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN OR GASTROINTESTINAL DISORDERS | AstraZeneca AB (SE) | 2005-08-17 | — | — | EP | disclosed |
| US-20040147526-A1 | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2004-07-29 | — | — | US | disclosed |
| WO-2004041802-A1 | 4(PHENYL-PIPERAZINYL-METHYL) BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN OR GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2004-05-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149717-A1 | Diarylmethyl Piperazine Derivatives, Preparations Thereof and Uses Thereof | OPRM1, OPRL1, PNMT | OPRD1 8/4885OPRM1 1/4885OPRK1 7/4885 |
| US-20060122193-A1 | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain or gastrointestinal disorders | OPRK1, TRPV1, OPRM1 | OPRD1 5/4885OPRM1 3/4885OPRK1 1/4885 |
| US-20070270435-A1 | Novel Compounds | FFAR3, CNR1, INSR | OPRD1 15/4885OPRM1 181/4885OPRK1 146/4885 |
| US-20040147526-A1 | 4(Phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders | HTR2C, OPRM1, HTR3C | OPRD1 7/4885OPRM1 2/4885OPRK1 8/4885 |
| US-20110039858-A1 | Novel Compounds | FFAR3, CNR1, INSR | OPRD1 14/4885OPRM1 181/4885OPRK1 145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.