SCHEMBL9925857

SCHEMBL9925857

COC(=O)[C@H](CO)NC(=O)c1ccc(C(=O)c2ccccc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.56
RAB9A P51151 2/20 0.56
GAA P10253 2/20 0.54
LMNA P02545 1/20 0.50
GLA P06280 1/20 0.50
CYP26A1 O43174 1/20 0.50
TAS1R3 Q7RTX0 4/20 0.48
TAS1R1 Q7RTX1 4/20 0.48
GPR139 Q6DWJ6 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
THRB P10828 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
HSD17B10 Q99714 1/20 0.47
CA2 P00918 2/20 0.47
PTGS1 P23219 1/20 0.47
PTGS2 P35354 1/20 0.47
CA1 P00915 1/20 0.47
CTSL P07711 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10024019 0.94 GAA (0.56) ALDH1A1RAB9AGAALMNAGLA
SCHEMBL5672076 0.94 GAA (0.56) ALDH1A1RAB9AGAALMNAGLA
SCHEMBL8054837 0.86 KMT2A (0.47) ALDH1A1RAB9AGAALMNACYP26A1
SCHEMBL8054835 0.86 KMT2A (0.47) ALDH1A1RAB9AGAALMNACYP26A1
SCHEMBL13885653 0.83 LNPEP (0.56) RAB9AGAATAS1R3TAS1R1L3MBTL1
SCHEMBL12983609 0.83 TAS1R3 (0.52) ALDH1A1RAB9AGAATAS1R3TAS1R1
SCHEMBL12983607 0.83 TAS1R3 (0.52) ALDH1A1RAB9AGAATAS1R3TAS1R1
SCHEMBL21663897 0.82 TAS1R3 (0.50) ALDH1A1RAB9AGAALMNATAS1R3
SCHEMBL5995873 0.82 ALDH1A1 (0.51) ALDH1A1RAB9AGAALMNATAS1R3
SCHEMBL29241144 0.82 TAS1R3 (0.50) RAB9AGAACYP26A1TAS1R3TAS1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1618087-B1 ANTIBACTERIAL AGENTS NOVARTIS VACCINES & DIAGNOSTIC (US) 2012-06-13 EP disclosed