Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | HTR1A | P08908 | 1/20 | 0.67 |
| ▸ | MAOA | P21397 | 1/20 | 0.67 |
| ▸ | MAOB | P27338 | 1/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.67 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL279958 | 0.81 | CYP2C19 (0.72) | ALDH1A1HTR1AMAOAMAOBKCNH2 | |
| SCHEMBL3281638 | 0.81 | ALDH1A1 (0.67) | ALDH1A1HTR1AMAOAMAOBKCNH2 | |
| SCHEMBL280240 | 0.80 | MEN1 (0.76) | ALDH1A1HTR1AMAOAMAOBKCNH2 | |
| Moclobemide SCHEMBL3408310 | 0.80 | CD274 (1.00) | ALDH1A1HTR1AMAOAMAOBKCNH2 | |
| Moclobemide SCHEMBL49708 | 0.80 | CD274 (1.00) | ALDH1A1HTR1AMAOAMAOBKCNH2 | |
| SCHEMBL13632449 | 0.80 | POLB (0.62) | ALDH1A1HTR1AMAOAMAOBKCNH2 | |
| Moclobemide SCHEMBL11475483 | 0.79 | CD274 (0.97) | ALDH1A1HTR1AMAOAMAOBKCNH2 | |
| SCHEMBL14023396 | 0.78 | LMNA (0.61) | ALDH1A1CD274POLBKDM4ETP53 | |
| SCHEMBL16574185 | 0.77 | CD274 (0.79) | ALDH1A1HTR1AMAOAMAOBKCNH2 | |
| SCHEMBL14435528 | 0.77 | POLB (1.00) | ALDH1A1HTR1AMAOAMAOBKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149661-A1 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS | NOVARTIS AG (CH) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149661-A1 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS | MDM4, MDM2, TP53 | ALDH1A1 4361/4885HTR1A 1020/4885MAOA 2314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.