SCHEMBL9928248

SCHEMBL9928248

COc1ccc(/C(=C(/C)CC(=O)O)c2ccccc2)c2c1OC(C)(C)C2

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 4/20 0.42
KDM4E B2RXH2 3/20 0.40
CASP1 P29466 1/20 0.40
CASP7 P55210 1/20 0.40
KMT2A Q03164 1/20 0.40
NPC1 O15118 3/20 0.38
RAB9A P51151 2/20 0.38
HSD17B10 Q99714 2/20 0.36
MAPT P10636 1/20 0.36
ALOX15 P16050 1/20 0.36
MAPK1 P28482 1/20 0.36
ALDH1A1 P00352 1/20 0.36
LMNA P02545 1/20 0.36
HTT P42858 1/20 0.35
CYP19A1 P11511 2/20 0.35
DRD2 P14416 1/20 0.35
HTR2A P28223 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5723240 0.83 MAPT (0.52) FFAR4KDM4EKMT2ANPC1RAB9A
SCHEMBL6031384 0.79 FFAR4 (0.51) FFAR4KDM4ECASP1CASP7KMT2A
SCHEMBL7360407 0.78 FFAR4 (0.46) FFAR4KDM4ECASP1CASP7KMT2A
SCHEMBL5722811 0.78 KDM4E (0.54) FFAR4KDM4ECASP1CASP7KMT2A
SCHEMBL8068920 0.76 FFAR4 (0.43) FFAR4KDM4ECASP1CASP7KMT2A
SCHEMBL183890 0.74 FFAR4 (0.44) FFAR4KDM4ECASP1CASP7KMT2A
SCHEMBL3452752 0.74 FFAR4 (0.46) FFAR4KDM4ECASP1CASP7KMT2A
SCHEMBL7360394 0.70 FFAR4 (0.46) FFAR4KDM4ECASP1CASP7KMT2A
SCHEMBL8940054 0.70 FFAR4 (0.44) FFAR4KDM4ECASP1CASP7KMT2A
SCHEMBL5722878 0.69 CYP19A1 (0.45) FFAR4KMT2ANPC1RAB9AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120145974-A1 CHROMENE COMPOUND TOKUYAMA CORPORATION (JP) 2012-06-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120145974-A1 CHROMENE COMPOUND CRY2, CYP2J2, NR0B2 FFAR4 3957/4885KDM4E 3039/4885CASP1 1176/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.