Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | CES1 | P23141 | 2/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 2/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | VCP | P55072 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citrazinic Acid SCHEMBL15022514 | 0.82 | NOTUM (0.39) | DAOTSHRALDH1A1HSD17B10NOTUM | |
| SCHEMBL17961177 | 0.79 | SMN1; SMN2 (0.47) | TSHRALDH1A1HSD17B10TP53L3MBTL1 | |
| SCHEMBL11333696 | 0.77 | — | — | |
| SCHEMBL11854680 | 0.77 | — | — | |
| Boric Acid SCHEMBL5724736 | 0.76 | ADORA1 (0.34) | — | |
| SCHEMBL15022628 | 0.75 | KDM4E (0.41) | TSHRALDH1A1HSD17B10TP53SMN1; SMN2 | |
| SCHEMBL2023841 | 0.72 | ADORA1 (0.34) | TP53L3MBTL1 | |
| Benzoic Acid SCHEMBL28693411 | 0.71 | TSHR (0.78) | DAOTSHRNAPRTALDH1A1CES2 | |
| Benzoic Acid SCHEMBL9705228 | 0.71 | TSHR (0.78) | DAOTSHRNAPRTALDH1A1CES2 | |
| Benzoic Acid SCHEMBL2400344 | 0.71 | TSHR (0.78) | DAOTSHRNAPRTALDH1A1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8455573-B2 | Curable composition comprising imidazolium monocarboxylate salt | E I DU PONT DE NEMOURS AND COMPANY (US) | 2013-06-04 | — | — | US | claimed |
| WO-2012088158-A2 | CURABLE EPOXY COMPOSITION COMPRISING IMIDAZOLIUM SALTS AND METHOD FOR CURING SAME | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-06-28 | — | — | WO | claimed |
| WO-2012088163-A2 | METHOD FOR PREPARING A CONFORMALLY SEALED PRINTED WIRING BOARD USING A COATED SUBSTRATE COMPRISING A CURABLE EPOXY COMPOSITION COMPRISING IMIDAZOLIUM SALTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-06-28 | — | — | WO | claimed |
| WO-2012088160-A2 | A COATED SUBSTRATE COMPRISING A CURABLE EPOXY COMPOSITION COMPRISING IMIDAZOLIUM SALTS AND METHOD FOR PREPARING SAME | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-06-28 | — | — | WO | claimed |
| WO-2012088148-A2 | LATENT CURE CATALYST BASED UPON IMIDAZOLIUM SALTS USEFUL FOR EPOXY COMPOSITIONS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-06-28 | — | — | WO | claimed |
| US-20120157572-A1 | CURABLE COMPOSITION COMPRISING IMIDAZOLIUM MONOCARBOXYLATE SALT | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-06-21 | — | — | US | claimed |
| US-20120152458-A1 | METHOD FOR PREPARING MULTILAYER ARTICLE BY CURING A CURABLE COMPOSITION COMPRISING IMIDAZOLIUM MONOCARBOXYLATE SALT | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-06-21 | — | — | US | claimed |
| US-20120156474-A1 | ARTICLE HAVING CURABLE COATING COMPRISING IMIDAZOLIUM MONOCARBOXYLATE SALT | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-06-21 | — | — | US | claimed |
| US-20120157688-A1 | IMIDAZOLIUM MONOCARBOXYLATE SALT AND METHOD FOR PREPARATION THEREOF | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-06-21 | — | — | US | claimed |
| US-8455573-B2 | Curable composition comprising imidazolium monocarboxylate salt | E I DU PONT DE NEMOURS AND COMPANY (US) | 2013-06-04 | — | — | US | disclosed |
| WO-2012088160-A2 | A COATED SUBSTRATE COMPRISING A CURABLE EPOXY COMPOSITION COMPRISING IMIDAZOLIUM SALTS AND METHOD FOR PREPARING SAME | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012088163-A2 | METHOD FOR PREPARING A CONFORMALLY SEALED PRINTED WIRING BOARD USING A COATED SUBSTRATE COMPRISING A CURABLE EPOXY COMPOSITION COMPRISING IMIDAZOLIUM SALTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012088158-A2 | CURABLE EPOXY COMPOSITION COMPRISING IMIDAZOLIUM SALTS AND METHOD FOR CURING SAME | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012088148-A2 | LATENT CURE CATALYST BASED UPON IMIDAZOLIUM SALTS USEFUL FOR EPOXY COMPOSITIONS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-06-28 | — | — | WO | disclosed |
| US-20120157688-A1 | IMIDAZOLIUM MONOCARBOXYLATE SALT AND METHOD FOR PREPARATION THEREOF | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-06-21 | — | — | US | disclosed |
| US-20120157572-A1 | CURABLE COMPOSITION COMPRISING IMIDAZOLIUM MONOCARBOXYLATE SALT | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-06-21 | — | — | US | disclosed |
| US-20120152458-A1 | METHOD FOR PREPARING MULTILAYER ARTICLE BY CURING A CURABLE COMPOSITION COMPRISING IMIDAZOLIUM MONOCARBOXYLATE SALT | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-06-21 | — | — | US | disclosed |
| US-20120156474-A1 | ARTICLE HAVING CURABLE COATING COMPRISING IMIDAZOLIUM MONOCARBOXYLATE SALT | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157688-A1 | IMIDAZOLIUM MONOCARBOXYLATE SALT AND METHOD FOR PREPARATION THEREOF | EHMT2, EHMT1, PICALM | DAO 2428/4885TSHR 4884/4885NAPRT 1551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.