Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9930605 | 0.89 | SIRT2 (0.45) | HCAR3ALDH1A1KDM4ESIRT2PRKCI | |
| SCHEMBL9930617 | 0.88 | CSNK2A1 (0.39) | ALDH1A1KDM4EKMT2ALMNAHTT | |
| SCHEMBL9930301 | 0.86 | AURKA (0.35) | KDM4EMEN1KMT2ARAF1ATM | |
| SCHEMBL15541357 | 0.86 | CSNK2A1 (0.43) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL9931108 | 0.86 | HCAR3 (0.43) | HCAR3ALDH1A1KDM4EKMT2AHPGD | |
| SCHEMBL9930959 | 0.84 | HCAR3 (0.42) | HCAR3KDM6BKDM4CALDH1A1MEN1 | |
| SCHEMBL9930438 | 0.83 | JAK2 (0.42) | ALDH1A1RAF1SIRT2PRKCIBRAF | |
| SCHEMBL9930841 | 0.81 | YTHDC1 (0.35) | HCAR3ALDH1A1LMNARAF1POLB | |
| SCHEMBL9930627 | 0.80 | EIF4EBP1 (0.35) | SIRT2L3MBTL1BRAFLPAR2MAPT | |
| SCHEMBL9930898 | 0.80 | LPAR1 (0.35) | ALDH1A1KDM4ERAF1PRKCIBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157439-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157439-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | BRAF, RAF1, ARAF | HCAR3 4156/4885KDM6B 3646/4885KDM4C 3920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.