Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4EBP1 | Q13541 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 8/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 8/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | ULK1 | O75385 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.31 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | AKT2 | P31751 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9930438 | 0.87 | JAK2 (0.42) | BRAFSIRT2MAPK8MAPTLPAR1 | |
| SCHEMBL9930301 | 0.83 | AURKA (0.35) | AURKARPS6KB1AURKBERN1BRAF | |
| SCHEMBL9930605 | 0.82 | SIRT2 (0.45) | AURKARPS6KB1BRAFSIRT2MAPT | |
| SCHEMBL9930898 | 0.82 | LPAR1 (0.35) | EIF4EBP1AURKARPS6KB1ERN1BRAF | |
| SCHEMBL9930617 | 0.81 | CSNK2A1 (0.39) | AURKAMAPTL3MBTL1 | |
| SCHEMBL9930221 | 0.80 | HCAR3 (0.40) | BRAFSIRT2MAPTL3MBTL1LPAR2 | |
| SCHEMBL9930959 | 0.80 | HCAR3 (0.42) | AURKARPS6KB1MAPTLPAR1LPAR2 | |
| SCHEMBL9930988 | 0.78 | AURKA (0.43) | AURKARPS6KB1GRM1ERN1BRAF | |
| SCHEMBL9930841 | 0.77 | YTHDC1 (0.35) | BRAFMAPTLPAR1LPAR2 | |
| SCHEMBL9931108 | 0.77 | HCAR3 (0.43) | AURKARPS6KB1CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157439-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157439-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | BRAF, RAF1, ARAF | EIF4EBP1 787/4885AURKA 1013/4885RPS6KB1 315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.