Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | THRB | P10828 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25606724 | 0.96 | KDM4E (0.36) | KDM4EALDH1A1HPGDHTTMEN1 | |
| SCHEMBL25717698 | 0.94 | KDM4E (0.35) | KDM4EALDH1A1HPGDHTTMEN1 | |
| SCHEMBL25607147 | 0.93 | KDM4E (0.34) | KDM4EALDH1A1HPGDHTTMEN1 | |
| SCHEMBL29664183 | 0.93 | PGR (0.34) | KDM4EALDH1A1HPGDHTTMEN1 | |
| SCHEMBL1680041 | 0.93 | PGR (0.34) | KDM4EALDH1A1HPGDHTTMEN1 | |
| SCHEMBL9934603 | 0.92 | AURKA (0.34) | KDM4EALDH1A1HPGDHTTMEN1 | |
| SCHEMBL12424586 | 0.92 | KDM4E (0.35) | KDM4EALDH1A1HPGDHTTMEN1 | |
| SCHEMBL25717696 | 0.92 | KDM4E (0.36) | KDM4EALDH1A1HPGDHTTMEN1 | |
| SCHEMBL1009516 | 0.91 | PGR (0.32) | KDM4EALDH1A1HPGDHTTMEN1 | |
| SCHEMBL29664129 | 0.91 | PGR (0.32) | KDM4EALDH1A1HPGDHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073838-B2 | Method of making indeno-fused naphthol materials | TRANSITIONS OPTICAL, INC. (US) | 2015-07-07 | — | — | US | disclosed |
| US-9073838-B2 | Method of making indeno-fused naphthol materials | TRANSITIONS OPTICAL, INC. (US) | 2015-07-07 | — | — | US | disclosed |
| US-9073838-B2 | Method of making indeno-fused naphthol materials | TRANSITIONS OPTICAL, INC. (US) | 2015-07-07 | — | — | US | disclosed |
| US-20140364618-A1 | Method of Making Indeno-Fused Naphthol Materials | TRANSITIONS OPTICALS, INC. (US) | 2014-12-11 | — | — | US | disclosed |
| US-20140364618-A1 | Method of Making Indeno-Fused Naphthol Materials | TRANSITIONS OPTICALS, INC. (US) | 2014-12-11 | — | — | US | disclosed |
| US-20140364618-A1 | Method of Making Indeno-Fused Naphthol Materials | TRANSITIONS OPTICALS, INC. (US) | 2014-12-11 | — | — | US | disclosed |
| US-8765978-B2 | Method of making indeno-fused naphthol materials | TRANSITIONS OPTICAL, INC. (US) | 2014-07-01 | — | — | US | disclosed |
| US-20120157696-A1 | METHOD OF MAKING INDENO-FUSED NAPHTHOL MATERIALS | TRANSITIONS OPTICAL, INC. (US) | 2012-06-21 | — | — | US | disclosed |
| WO-2012082837-A1 | METHOD OF MAKING INDENO-FUSED NAPHTHOL MATERIALS | TRANSITIONS OPTICAL, INC. (US) | 2012-06-21 | — | — | WO | disclosed |
| US-20120157696-A1 | METHOD OF MAKING INDENO-FUSED NAPHTHOL MATERIALS | TRANSITIONS OPTICAL, INC. (US) | 2012-06-21 | — | — | US | disclosed |
| US-20120157696-A1 | METHOD OF MAKING INDENO-FUSED NAPHTHOL MATERIALS | TRANSITIONS OPTICAL, INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140364618-A1 | Method of Making Indeno-Fused Naphthol Materials | IDH3A, NQO1, IDH3B | KDM4E 1771/4885ALDH1A1 494/4885HPGD 12/4885 |
| US-20120157696-A1 | METHOD OF MAKING INDENO-FUSED NAPHTHOL MATERIALS | NQO1, IDH3A, IDH2 | KDM4E 2270/4885ALDH1A1 521/4885HPGD 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.