SCHEMBL25607147

SCHEMBL25607147

COc1ccc(C2(c3ccc(-c4ccccc4)cc3)C=Cc3c4c(c5ccc(OC)cc5c3O2)-c2ccccc2C4(C)C)cc1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.34
ALDH1A1 P00352 3/20 0.34
HPGD P15428 3/20 0.34
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
CYP2C9 P11712 2/20 0.34
CYP2C19 P33261 2/20 0.34
LMNA P02545 1/20 0.34
TSHR P16473 1/20 0.34
HTT P42858 1/20 0.34
HSD17B10 Q99714 1/20 0.34
GPR84 Q9NQS5 2/20 0.32
PIN1 Q13526 1/20 0.32
PDK2 Q15119 1/20 0.32
EDNRB P24530 1/20 0.31
EDNRA P25101 1/20 0.31
PGR P06401 1/20 0.30
NPC1 O15118 1/20 0.30
TP53 P04637 1/20 0.30
CYP3A4 P08684 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25717698 0.95 KDM4E (0.35) KDM4EALDH1A1HPGDMEN1KMT2A
SCHEMBL25606724 0.95 KDM4E (0.36) KDM4EALDH1A1HPGDMEN1KMT2A
SCHEMBL25604650 0.94 GPR84 (0.34) KDM4EALDH1A1HPGDMEN1KMT2A
SCHEMBL25844403 0.94 GPR84 (0.34) KDM4EALDH1A1HPGDMEN1KMT2A
SCHEMBL25717696 0.93 KDM4E (0.36) KDM4EALDH1A1HPGDMEN1KMT2A
SCHEMBL9932623 0.93 KDM4E (0.36) KDM4EALDH1A1HPGDMEN1KMT2A
SCHEMBL25607194 0.93 KDM4E (0.33) KDM4EALDH1A1HPGDMEN1KMT2A
SCHEMBL12424586 0.92 KDM4E (0.35) KDM4EALDH1A1HPGDMEN1KMT2A
SCHEMBL25607146 0.91 GPR84 (0.36) KDM4EALDH1A1HPGDMEN1KMT2A
SCHEMBL9899115 0.91 KDM4E (0.34) KDM4EALDH1A1HPGDMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230340318-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES HOYA LENS THAILAND LTD. (TH) 2023-10-26 US disclosed
US-20230340318-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES HOYA LENS THAILAND LTD. (TH) 2023-10-26 US disclosed
US-20230227717-A1 PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND SPECTACLES HOYA LENS THAILAND LTD. (TH) 2023-07-20 US disclosed
US-20230227717-A1 PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND SPECTACLES HOYA LENS THAILAND LTD. (TH) 2023-07-20 US disclosed
EP-4198102-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES Hoya Lens Thailand Ltd. (TH) 2023-06-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230340318-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES NR2E3, CRY1, RPS10 KDM4E 3270/4885ALDH1A1 1091/4885HPGD 3213/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.