Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | TTR | P02766 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL95180 | 0.82 | CYP3A4 (0.58) | THRBCYP3A4ALDH1A1GAAMAPT | |
| SCHEMBL93999 | 0.82 | THRB (1.00) | THRBCYP3A4ALDH1A1GAAMAPT | |
| Hydrochloric Acid SCHEMBL4929431 | 0.79 | CYP3A4 (0.55) | THRBCYP3A4ALDH1A1GAAMAPT | |
| Hydrochloric Acid SCHEMBL7755405 | 0.79 | THRB (0.94) | THRBCYP3A4ALDH1A1GAAMAPT | |
| Hydrochloric Acid SCHEMBL10336483 | 0.79 | THRB (0.94) | THRBCYP3A4ALDH1A1GAAMAPT | |
| SCHEMBL9453347 | 0.79 | THRB (0.94) | THRBCYP3A4ALDH1A1GAAMAPT | |
| SCHEMBL5271617 | 0.79 | THRB (0.94) | THRBCYP3A4ALDH1A1GAAMAPT | |
| SCHEMBL2417306 | 0.77 | TSHR (0.68) | THRBCYP3A4ALDH1A1MAPTCA1 | |
| Hydrochloric Acid SCHEMBL10336482 | 0.75 | THRB (0.84) | THRBCYP3A4ALDH1A1GAAMAPT | |
| SCHEMBL21695780 | 0.75 | GAA (0.50) | THRBCYP3A4ALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122036699-A | THR-beta modulators and methods of use thereof | 阿利戈斯治疗公司 | 2026-05-15 | — | — | CN | disclosed |
| US-20250304561-A1 | MODULATORS OF THR-BETA AND METHODS OF USE THEREOF | ALIGOS THERAPEUTICS, INC. (US) | 2025-10-02 | — | — | US | disclosed |
| EP-4523692-A2 | MODULATORS OF THR-SS AND METHODS OF USE THEREOF | Aligos Therapeutics, Inc. (US) | 2025-03-19 | — | — | EP | disclosed |
| EP-3965884-B1 | MODULATORS OF THR-BETA WITH A DIOXO-1,2,4-TRIAZYL HEAD GROUP | ALIGOS THERAPEUTICS INC (US) | 2025-01-15 | — | — | EP | disclosed |
| US-12180192-B2 | Modulators of THR-β and methods of use thereof | ALIGOS THERAPEUTICS, INC. (US) | 2024-12-31 | — | — | US | disclosed |
| US-11926618-B2 | Halogen-substituted phenylate compound and applications thereof | HINOVA PHARMACEUTICALS INC. (CN) | 2024-03-12 | — | — | US | disclosed |
| US-20220332707-A1 | HALOGEN-SUBSTITUTED PHENYLATE COMPOUND AND APPLICATIONS THEREOF | HINOVA PHARMACEUTICALS INC. (CN) | 2022-10-20 | — | — | US | disclosed |
| EP-4019510-A1 | HALOGEN-SUBSTITUTED PHENYLATE COMPOUND AND APPLICATIONS THEREOF | Hinova Pharmaceuticals Inc. (CN) | 2022-06-29 | — | — | EP | disclosed |
| EP-4019510-A1 | HALOGEN-SUBSTITUTED PHENYLATE COMPOUND AND APPLICATIONS THEREOF | Hinova Pharmaceuticals Inc. (CN) | 2022-06-29 | — | — | EP | disclosed |
| CN-112409340-B | Halogen substituted phenyl ether compound and application thereof | 海创药业股份有限公司 | 2022-03-18 | — | — | CN | disclosed |
| US-11091467-B2 | Modulators of THR-β and methods of use thereof | ALIGOS THERAPEUTICS, INC. (US) | 2021-08-17 | — | — | US | disclosed |
| CN-112409340-A | Halogen substituted phenyl ether compound and application thereof | 海创药业股份有限公司 | 2021-02-26 | — | — | CN | disclosed |
| WO-2021032161-A1 | HALOGEN-SUBSTITUTED PHENYLATE COMPOUND AND APPLICATIONS THEREOF | 成都海创药业有限公司 | 2021-02-25 | — | — | WO | disclosed |
| WO-2021032161-A1 | HALOGEN-SUBSTITUTED PHENYLATE COMPOUND AND APPLICATIONS THEREOF | 成都海创药业有限公司 | 2021-02-25 | — | — | WO | disclosed |
| WO-2020239076-A1 | PYRIDAZINONE DERIVATIVES AS THYROXINE RECEPTOR-Β AGONISTS AND APPLICATION THEREOF | 南京明德新药研发有限公司 | 2020-12-03 | — | — | WO | disclosed |
| WO-2020227549-A1 | MODULATORS OF THR-β AND METHODS OF USE THEREOF | ALIGOS THERAPEUTICS, INC. (US) | 2020-11-12 | — | — | WO | disclosed |
| US-20200354345-A1 | MODULATORS OF THR-BETA AND METHODS OF USE THEREOF | ALIGOS THERAPEUTICS, INC. (US) | 2020-11-12 | — | — | US | disclosed |
| US-20120157482-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC | 2012-06-21 | — | — | US | disclosed |
| US-4675290-A | CHROMATOGRAPHY OF THE ANILINE DYE PRODUCED BY COUPLING REACTI ON OF THE AMINE FORMED FROM THE AMIDE SUBSTRATE | TOYO JOZO KABUSHIKI KAISHA (JP) | 1987-06-23 | — | — | US | disclosed |
| US-4588836-A | LEUCYL- OR GLUTAMYL-3,5-DIHALO-4-HYDROXYANILIDES | TOYO JOZO KABUSHIKI KAISHA (JP) | 1986-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11926618-B2 | Halogen-substituted phenylate compound and applications thereof | THRB, FFAR3, THRA | THRB 1/4885CYP3A4 168/4885ALDH1A1 2721/4885 |
| US-20250304561-A1 | MODULATORS OF THR-BETA AND METHODS OF USE THEREOF | THRB, THRA, TRHR | THRB 1/4885CYP3A4 3296/4885ALDH1A1 3330/4885 |
| US-20200354345-A1 | MODULATORS OF THR-BETA AND METHODS OF USE THEREOF | THRB, THRA, TRHR | THRB 1/4885CYP3A4 3790/4885ALDH1A1 3081/4885 |
| US-20220332707-A1 | HALOGEN-SUBSTITUTED PHENYLATE COMPOUND AND APPLICATIONS THEREOF | THRB, FFAR3, THRA | THRB 1/4885CYP3A4 168/4885ALDH1A1 2721/4885 |
| US-12180192-B2 | Modulators of THR-β and methods of use thereof | THRB, THRA, TRHR | THRB 1/4885CYP3A4 3759/4885ALDH1A1 3049/4885 |
| US-20120157482-A1 | COMPOUNDS AND METHODS | NQO1, CYP1B1, CYP1A1 | THRB 2458/4885CYP3A4 23/4885ALDH1A1 52/4885 |
| US-11091467-B2 | Modulators of THR-β and methods of use thereof | THRB, THRA, TRHR | THRB 1/4885CYP3A4 3759/4885ALDH1A1 3049/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.