Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HTR3A | P46098 | 5/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.43 |
| ▸ | HTR3B | O95264 | 3/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9968519 | 0.94 | HTR3A (0.49) | KDM4ECYP3A4HSD17B10HTR3AHTR3E | |
| SCHEMBL9932793 | 0.85 | KDM4E (0.42) | KDM4ECYP3A4HSD17B10HTR3AHTR3E | |
| SCHEMBL9968420 | 0.82 | HTR3A (0.51) | KDM4EHTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL9931839 | 0.81 | MEN1 (0.46) | KDM4EALDH1A1NCF1POLBGAA | |
| SCHEMBL9968415 | 0.81 | MEN1 (0.41) | KDM4ECYP3A4HSD17B10HTR3AHTR3E | |
| SCHEMBL9932543 | 0.81 | SMO (0.45) | KDM4ECYP3A4HSD17B10ALDH1A1MAPK1 | |
| SCHEMBL9968416 | 0.79 | TSHR (0.43) | KDM4ECYP3A4HSD17B10ALDH1A1MAPK1 | |
| SCHEMBL9968419 | 0.79 | MEN1 (0.41) | KDM4ECYP3A4HSD17B10HTR3AHTR3E | |
| SCHEMBL9932626 | 0.79 | HSD11B1 (0.48) | ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL9932064 | 0.78 | ALDH1A1 (0.46) | ALDH1A1HTTPOLBGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | SMO, RB1, GLI1 | KDM4E 258/4885CYP3A4 3563/4885HSD17B10 3995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.