Sugi Predict

Sugi Predict / Compounds / SCHEMBL993456

SCHEMBL993456

SCHEMBL993456

CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)OC)c2cc(C(F)(F)F)ccc2N1C(=O)OC(C)C

nearest known ligand 0.85

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ CETP P11597 20/20 0.85

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL125282 1.00 CETP (0.85) CETP
SCHEMBL30468632 1.00 CETP (0.85) CETP
SCHEMBL6181329 0.94 CETP (0.74) CETP
SCHEMBL6181331 0.94 CETP (0.74) CETP
SCHEMBL994609 0.93 CETP (0.73) CETP
SCHEMBL6182867 0.93 CETP (0.73) CETP
SCHEMBL6182868 0.93 CETP (0.73) CETP
SCHEMBL2262660 0.93 CETP (0.73) CETP
SCHEMBL1565566 0.93 CETP (0.73) CETP
SCHEMBL992623 0.92 CETP (1.00) CETP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 264 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1469833-B1 METHOD FOR MAKING HOMOGENEOUS SPRAY-DRIED SOLID AMORPHOUS DRUG DISPERSIONS UTILIZING MODIFIED SPRAY-DRYING APPARATUS BEND RES INC (US) 2021-05-19 — — EP claimed
US-9265731-B2 Drying of drug-containing particles BEND RESEARCH, INC. (US) 2016-02-23 — — US claimed
EP-1855652-B1 DRYING OF DRUG-CONTAINING PARTICLES BEND RES INC (US) 2015-12-02 — — EP claimed
US-8828438-B2 Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors and HMG-CoA reductase BEND RESEARCH, INC. (US) 2014-09-09 — — US claimed
US-20110277339-A1 METHOD FOR MAKING HOMOGENEOUS SPRAY-DRIED SOLID AMORPHOUS DRUG DISPERSIONS UTILIZING MODIFIED SPRAY-DRYING APPARATUS LONZA BEND INC. 2011-11-17 — — US claimed
EP-2275091-A1 Pharmaceutical compositions comprising adsorbates of an amorphous drug Pfizer Products Inc. (US) 2011-01-19 — — EP claimed
US-7780988-B2 Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles BEND RESEARCH, INC. (US) 2010-08-24 — — US claimed
US-20090169583-A1 Solid Adsorbates of Hydrophobic Drugs PFIZER, INC. 2009-07-02 — — US claimed
US-20090118328-A1 Pharmaceutical Compositions Of Cholesteryl Ester Transfer Protein Inhibitors And Hmg-Coa Reductase BEND RESEARCH, INC. (US) 2009-05-07 — — US claimed
US-20080213375-A1 Drying of Drug-Containing Particles PFIZER INC. 2008-09-04 — — US claimed
WO-2003063831-A2 IMMEDIATE RELEASE DOSAGE FORMS CONTAINING SOLID DRUG DISPERSIONS PFIZER PRODUCTS INC. (US) 2003-08-07 — — WO claimed
US-6586448-B1 Cholesteryl ester transfer protein inhibitors used as antilipemic agents for prophylaxis of cardiovascular disorders PFIZER INC. 2003-07-01 — — US claimed
US-20030072801-A1 Pharmaceutical compositions comprising drug and concentration-enhancing polymers PFIZER INC. 2003-04-17 — — US claimed
US-20030054038-A1 Pharmaceutical compositions of drugs and neutralized acidic polymers BEND RESEARCH, INC. 2003-03-20 — — US claimed
US-20030022944-A1 Self-emulsifying formulations of cholesteryl ester transfer protein inhibitors PFIZER INC. 2003-01-30 — — US claimed
WO-2003000295-A2 SELF-EMULSIFYING FORMULATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS PFIZER PRODUCTS INC. (US) 2003-01-03 — — WO claimed
WO-2003000238-A1 PHARMACEUTICAL COMPOSITIONS OF ADSORBATES OF AMORPHOUS DRUG PFIZER PRODUCTS INC. (US) 2003-01-03 — — WO claimed
US-20020103225-A1 Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors BEND RESEARCH INC. 2002-08-01 — — US claimed
EP-1114031-A1 4-CARBOXYAMINO-2-SUBSTITUTED-1,2,3,4-TETRAHYDROQUINOLINES AS CETP INHIBITORS Pfizer Products Inc. (US) 2001-07-11 — — EP claimed
WO-2000017164-A1 4-CARBOXYAMINO-2-SUBSTITUTED-1,2,3,4-TETRAHYDROQUINOLINES AS CETP INHIBITORS PFIZER PRODUCTS INC. (US) 2000-03-30 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030072801-A1 Pharmaceutical compositions comprising drug and concentration-enhancing polymers ABCB1, ABCG2, CYP3A7 CETP 63/4885
US-20080213375-A1 Drying of Drug-Containing Particles NSF, PM20D2, PGA5 CETP 63/4885
US-20030054038-A1 Pharmaceutical compositions of drugs and neutralized acidic polymers PDE7A, CA6, PDE9A CETP 1214/4885
US-20090118328-A1 Pharmaceutical Compositions Of Cholesteryl Ester Transfer Protein Inhibitors And Hmg-Coa Reductase CETP, HMGCR, MTTP CETP 1/4885
US-20090169583-A1 Solid Adsorbates of Hydrophobic Drugs ABCG2, SLCO1B1, SLCO4C1 CETP 45/4885
US-20020103225-A1 Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors CETP, HDLBP, NPC1L1 CETP 1/4885
US-20030022944-A1 Self-emulsifying formulations of cholesteryl ester transfer protein inhibitors CETP, LCAT, LIPA CETP 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.