Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | RORB | Q92753 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9942157 | 0.85 | CFTR (0.49) | KDM4EALDH1A1HPGDCYP2C19CFTR | |
| SCHEMBL3961256 | 0.84 | KDM4E (0.44) | BACE1KDM4EALDH1A1HPGDCYP2C19 | |
| SCHEMBL3958362 | 0.81 | BACE1 (0.47) | BACE1KDM4EALDH1A1HPGDCYP2C19 | |
| SCHEMBL31435275 | 0.81 | BACE1 (0.47) | BACE1KDM4EALDH1A1HPGDCYP2C19 | |
| SCHEMBL1963621 | 0.78 | KDM4E (0.40) | BACE1KDM4EALDH1A1HPGDCYP2C19 | |
| SCHEMBL1009498 | 0.77 | TSHR (0.48) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL27165414 | 0.77 | CFD (0.39) | BACE1KDM4EALDH1A1HPGDCYP2C19 | |
| SCHEMBL27781533 | 0.75 | KDM4E (0.60) | BACE1KDM4EALDH1A1HPGDCYP2C19 | |
| SCHEMBL5943417 | 0.75 | KDM4E (0.73) | BACE1KDM4EALDH1A1HPGDCYP2C19 | |
| SCHEMBL9899201 | 0.75 | NR4A2 (0.46) | BACE1KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2652551-B1 | PHOTOCHROMIC COMPOUNDS, COMPOSITIONS AND ARTICLES | TRANSITIONS OPTICAL INC (US) | 2015-12-30 | — | — | EP | disclosed |
| US-8859097-B2 | Photochromic compounds, compositions and articles | TRANSITIONS OPTICAL, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| EP-2652551-A1 | PHOTOCHROMIC COMPOUNDS, COMPOSITIONS AND ARTICLES | Transitions Optical, Inc. (US) | 2013-10-23 | — | — | EP | disclosed |
| US-20120183810-A1 | PHOTOCHROMIC COMPOUNDS, COMPOSITIONS AND ARTICLES | TRANSITIONS OPTICAL, INC. (US) | 2012-07-19 | — | — | US | disclosed |
| WO-2012082236-A1 | PHOTOCHROMIC COMPOUNDS, COMPOSITIONS AND ARTICLES | TRANSITIONS OPTICAL, INC. (US) | 2012-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120183810-A1 | PHOTOCHROMIC COMPOUNDS, COMPOSITIONS AND ARTICLES | CRY2, H1-0, CRY1 | BACE1 1523/4885KDM4E 3170/4885ALDH1A1 2057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.