Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.73 |
| ▸ | HPGD | P15428 | 3/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.73 |
| ▸ | USP2 | O75604 | 1/20 | 0.73 |
| ▸ | CFTR | P13569 | 1/20 | 0.61 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11604499 | 0.88 | KDM4E (0.73) | KDM4EALDH1A1HPGDCYP2C19HSD17B10 | |
| SCHEMBL27781533 | 0.88 | KDM4E (0.60) | KDM4EALDH1A1HPGDCYP2C19HSD17B10 | |
| SCHEMBL15721293 | 0.87 | KDM4E (0.71) | KDM4EALDH1A1HPGDCYP2C19HSD17B10 | |
| SCHEMBL24901813 | 0.86 | CFTR (0.67) | KDM4EALDH1A1HPGDCYP2C19HSD17B10 | |
| SCHEMBL15684623 | 0.86 | KDM4E (0.79) | KDM4EALDH1A1HPGDCYP2C19HSD17B10 | |
| Triflusal SCHEMBL136423 | 0.84 | KDM4E (1.00) | KDM4EALDH1A1HPGDCYP2C19HSD17B10 | |
| Triflusal SCHEMBL29435449 | 0.84 | KDM4E (1.00) | KDM4EALDH1A1HPGDCYP2C19HSD17B10 | |
| Triflusal SCHEMBL29435450 | 0.84 | KDM4E (1.00) | KDM4EALDH1A1HPGDCYP2C19HSD17B10 | |
| SCHEMBL3056059 | 0.83 | KDM4E (0.75) | KDM4EALDH1A1HPGDCYP2C19HSD17B10 | |
| SCHEMBL15743761 | 0.83 | KDM4E (0.75) | KDM4EALDH1A1HPGDCYP2C19HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140315834-A1 | COMPOUNDS AND COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF INFLAMMATION-RELATED DISORDERS, PAIN AND FEVER, SKIN DISORDERS, CANCER AND PRECANCEROUS CONDITIONS THEREOF | MEDICON PHARMACEUTICALS, INC. (US) | 2014-10-23 | — | — | US | disclosed |
| US-20140121185-A1 | COMPOUNDS AND COMPOSITIONS FOR USE IN THE TREATMENT AND PREVENTION OF CANCER AND PRECANCEROUS CONDITIONS, INFLAMMATION-RELATED DISORDERS, PAIN AND FEVER | MEDICON PHARMACEUTICALS, INC. (US) | 2014-05-01 | — | — | US | disclosed |
| US-8173831-B2 | Fatty acid acetylated salicylates and their uses | CATABASIS PHARMACEUTICALS, INC. (US) | 2012-05-08 | — | — | US | disclosed |
| US-20100041748-A1 | FATTY ACID ACETYLATED SALICYLATES AND THEIR USES | CATABASIS PHARMACEUTICALS, INC. | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315834-A1 | COMPOUNDS AND COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF INFLAMMATION-RELATED DISORDERS, PAIN AND FEVER, SKIN DISORDERS, CANCER AND PRECANCEROUS CONDITIONS THEREOF | HMGB1, PTGES, FDPS | KDM4E 2957/4885ALDH1A1 339/4885HPGD 80/4885 |
| US-20100041748-A1 | FATTY ACID ACETYLATED SALICYLATES AND THEIR USES | FASN, ACACA, FABP4 | KDM4E 2493/4885ALDH1A1 285/4885HPGD 510/4885 |
| US-20140121185-A1 | COMPOUNDS AND COMPOSITIONS FOR USE IN THE TREATMENT AND PREVENTION OF CANCER AND PRECANCEROUS CONDITIONS, INFLAMMATION-RELATED DISORDERS, PAIN AND FEVER | PTGES, PTGES2, HSF1 | KDM4E 4531/4885ALDH1A1 837/4885HPGD 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.