Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.67 |
| ▸ | ESR1 | P03372 | 4/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.59 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | EBP | Q15125 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7074594 | 0.83 | LTA4H (0.67) | LTA4HESR1ESR2CHRNB2CHRNA4 | |
| SCHEMBL2741676 | 0.81 | LTA4H (0.64) | LTA4HESR1ESR2MCHR1MMP1 | |
| SCHEMBL185585 | 0.80 | HRH3 (0.70) | LTA4HESR1ESR2CHRNB2CHRNA4 | |
| SCHEMBL14174986 | 0.80 | LTA4H (0.63) | LTA4HESR1ESR2CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL223267 | 0.80 | LTA4H (0.62) | LTA4HESR1ESR2MCHR1MMP1 | |
| SCHEMBL5113291 | 0.79 | LTA4H (0.61) | LTA4HESR1ESR2CHRNB2CHRNA4 | |
| SCHEMBL6802602 | 0.79 | LTA4H (0.61) | LTA4HESR1ESR2CHRNB2CHRNA4 | |
| SCHEMBL6443597 | 0.78 | LTA4H (0.75) | LTA4HESR1ESR2CHRNB2CHRNA4 | |
| SCHEMBL20550862 | 0.77 | HRH3 (0.51) | LTA4HHRH3KCNH2KEAP1NFE2L2 | |
| SCHEMBL9935084 | 0.77 | CYP2D6 (0.66) | LTA4HESR1MCHR1HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012079154-A1 | SELECTIVE ESTROGEN RECEPTOR MODULATORS | DALHOUSIE UNIVERSITY (CA) | 2012-06-21 | — | — | WO | disclosed |