SCHEMBL9937196

SCHEMBL9937196

O=C1CC(Cc2ccc(O)cc2O)C(=O)N1CC(O)CN1C(=O)CC(Cc2ccc(O)cc2O)C1=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.37
CA1 P00915 1/20 0.37
CA4 P22748 1/20 0.37
CA5A P35218 1/20 0.37
CA9 Q16790 1/20 0.37
CA14 Q9ULX7 1/20 0.37
CA5B Q9Y2D0 1/20 0.37
TSHR P16473 3/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
TYR P14679 3/20 0.36
TACR1 P25103 1/20 0.35
PER2 O15055 3/20 0.34
ALDH1A1 P00352 3/20 0.34
CRY2 Q49AN0 1/20 0.34
CA3 P07451 1/20 0.33
MEN1 O00255 1/20 0.33
USP2 O75604 1/20 0.33
POLB P06746 1/20 0.33
MAPT P10636 1/20 0.33
PKM P14618 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9937327 0.94 CA12 (0.35) CA12CA1CA4CA5ACA9
SCHEMBL9937195 0.89 ALDH1A1 (0.39) TSHRL3MBTL1TYRTACR1ALDH1A1
SCHEMBL15341257 0.87 TYR (0.40) TSHRL3MBTL1TYRTACR1ALDH1A1
SCHEMBL9968851 0.87 ALDH1A1 (0.41) TSHRL3MBTL1TYRTACR1ALDH1A1
SCHEMBL9937177 0.84 L3MBTL1 (0.40) TSHRL3MBTL1TYRTACR1ALDH1A1
SCHEMBL9969790 0.84 ALDH1A1 (0.42) TSHRL3MBTL1TYRTACR1ALDH1A1
SCHEMBL9937438 0.83 ALDH1A1 (0.39) TSHRL3MBTL1TYRTACR1ALDH1A1
SCHEMBL9938471 0.82 CYP19A1 (0.41) TSHRL3MBTL1TYRTACR1ALDH1A1
SCHEMBL9938468 0.82 TSHR (0.56) TSHRL3MBTL1TYRTACR1ALDH1A1
SCHEMBL15328838 0.81 TSHR (0.43) TSHRL3MBTL1TYRTACR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8937187-B2 Method for depigmenting keratin materials using resorcinol derivatives L'OREAL (FR) 2015-01-20 US claimed
US-20130281507-A1 METHOD FOR DEPIGMENTING KERATIN MATERIALS USING RESORCINOL DERIVATIVES L'OREAL (FR) 2013-10-24 US claimed
EP-2651886-A1 METHOD FOR DEPIGMENTING KERATIN MATERIALS USING RESORCINOL DERIVATIVES L'Oréal (FR) 2013-10-23 EP claimed
WO-2012079938-A1 METHOD FOR DEPIGMENTING KERATIN MATERIALS USING RESORCINOL DERIVATIVES L'OREAL (FR) 2012-06-21 WO claimed
US-8937187-B2 Method for depigmenting keratin materials using resorcinol derivatives L'OREAL (FR) 2015-01-20 US disclosed
US-8937187-B2 Method for depigmenting keratin materials using resorcinol derivatives L'OREAL (FR) 2015-01-20 US disclosed
US-8937187-B2 Method for depigmenting keratin materials using resorcinol derivatives L'OREAL (FR) 2015-01-20 US disclosed
US-20130281507-A1 METHOD FOR DEPIGMENTING KERATIN MATERIALS USING RESORCINOL DERIVATIVES L'OREAL (FR) 2013-10-24 US disclosed
US-20130281507-A1 METHOD FOR DEPIGMENTING KERATIN MATERIALS USING RESORCINOL DERIVATIVES L'OREAL (FR) 2013-10-24 US disclosed
US-20130281507-A1 METHOD FOR DEPIGMENTING KERATIN MATERIALS USING RESORCINOL DERIVATIVES L'OREAL (FR) 2013-10-24 US disclosed
WO-2012079938-A1 METHOD FOR DEPIGMENTING KERATIN MATERIALS USING RESORCINOL DERIVATIVES L'OREAL (FR) 2012-06-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130281507-A1 METHOD FOR DEPIGMENTING KERATIN MATERIALS USING RESORCINOL DERIVATIVES KRT18, KLHL20, IK CA12 2917/4885CA1 4514/4885CA4 2045/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.