Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 3/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 12/20 | 0.36 |
| ▸ | TPSD1 | Q9BZJ3 | 12/20 | 0.36 |
| ▸ | TPSG1 | Q9NRR2 | 12/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5253414 | 0.83 | HSD17B10 (0.45) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL13604577 | 0.83 | HSD17B10 (0.45) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL9937434 | 0.81 | CHRM2 (0.37) | PRSS1F2ALDH1A1AGTR2TPSAB1 | |
| SCHEMBL12820517 | 0.79 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL16458941 | 0.78 | HSD17B10 (0.46) | SMN1; SMN2 | |
| SCHEMBL31713595 | 0.78 | TSHR (0.44) | ALDH1A1SMN1; SMN2AGTR2RAB9A | |
| SCHEMBL31754849 | 0.78 | TSHR (0.44) | ALDH1A1SMN1; SMN2AGTR2RAB9A | |
| SCHEMBL375868 | 0.76 | TPSAB1 (0.36) | PRSS1ALDH1A1SMN1; SMN2AGTR2TPSAB1 | |
| SCHEMBL8402776 | 0.76 | AGTR2 (0.47) | AGTR2 | |
| SCHEMBL6653686 | 0.76 | AGTR2 (0.47) | AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2864318-A1 | 2-AMINOPYRAZINE DERIVATIVES AS CSF-1 R KINASE INHIBITORS | Chroma Therapeutics Ltd. (GB) | 2015-04-29 | — | — | EP | disclosed |
| WO-2014001802-A1 | 2-AMINOPYRAZINE DERIVATIVES AS CSF-1 R KINASE INHIBITORS | CHROMA THERAPEUTICS LTD (GB) | 2014-01-03 | — | — | WO | disclosed |
| EP-2651454-A1 | IMAGING AGENTS | Chroma Therapeutics Ltd. (GB) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012080705-A1 | IMAGING AGENTS | CHROMA THERAPEUTICS LTD (GB) | 2012-06-21 | — | — | WO | disclosed |