Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TERT | O14746 | 7/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 3/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 3/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9967921 | 0.98 | NPC1 (0.44) | NPC1POLBGAAMAPTRAD52 | |
| Bromide SCHEMBL9938364 | 0.96 | NPC1 (0.46) | NPC1POLBGAAMAPTRAD52 | |
| Hydrochloric Acid SCHEMBL18824462 | 0.86 | CTSD (0.39) | NPC1POLBGAAMAPTRAD52 | |
| SCHEMBL18850905 | 0.84 | CTSD (0.41) | NPC1POLBGAAMAPTRAD52 | |
| SCHEMBL19505581 | 0.79 | NPC1 (0.44) | NPC1POLBGAAMAPTRAD52 | |
| SCHEMBL17591541 | 0.79 | TSHR (0.46) | MAPTKMT2ATERTAPOBEC3AAPOBEC3G | |
| SCHEMBL26577971 | 0.79 | CTSD (0.37) | POLBTERTCTDSP1ALDH1A1CTSD | |
| SCHEMBL18824429 | 0.79 | AOC3 (0.33) | KMT2AALDH1A1CTSDAOC3 | |
| Bromide SCHEMBL19439475 | 0.77 | TSHR (0.44) | MAPTKMT2ATERTAPOBEC3AAPOBEC3G | |
| SCHEMBL9967918 | 0.76 | PABPC1 (0.45) | NPC1POLBGAAMAPTRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9533296-B2 | Bleach catalysts | BASF SE (DE) | 2017-01-03 | — | — | US | disclosed |
| US-20160136627-A1 | Bleach Catalysts | BASF SE (DE) | 2016-05-19 | — | — | US | disclosed |
| US-9296713-B2 | Bleach catalysts | BASF SE (DE) | 2016-03-29 | — | — | US | disclosed |
| EP-2805942-B1 | Bleach catalysts | BASF SE (DE) | 2016-03-16 | — | — | EP | disclosed |
| US-20150225357-A1 | BLEACH CATALYSTS | HENKEL AG & CO. KGAA (DE) | 2015-08-13 | — | — | US | disclosed |
| US-9051285-B2 | Bleach catalysts | BASF SE (DE) | 2015-06-09 | — | — | US | disclosed |
| EP-2805942-A1 | Bleach catalysts | BASF SE (DE) | 2014-11-26 | — | — | EP | disclosed |
| EP-2651907-B1 | BLEACH CATALYSTS | BASF SE (DE) | 2014-10-01 | — | — | EP | disclosed |
| EP-2651907-A1 | BLEACH CATALYSTS | BASF SE (DE) | 2013-10-23 | — | — | EP | disclosed |
| US-20130261041-A1 | BLEACH CATALYSTS | HENKEL AG & CO. KGAA (DE) | 2013-10-03 | — | — | US | disclosed |
| WO-2012080088-A1 | BLEACH CATALYSTS | BASF SE (DE) | 2012-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160136627-A1 | Bleach Catalysts | APEH, H1-4, ALKBH2 | NPC1 4673/4885POLB 889/4885GAA 650/4885 |
| US-20130261041-A1 | BLEACH CATALYSTS | APEH, H1-4, ALKBH2 | NPC1 4673/4885POLB 889/4885GAA 650/4885 |
| US-20150225357-A1 | BLEACH CATALYSTS | CAT, APEH, ALKBH2 | NPC1 4681/4885POLB 701/4885GAA 400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.