Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.59 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.56 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.52 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.52 |
| ▸ | PTPRC | P08575 | 2/20 | 0.51 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.51 |
| ▸ | PTPRB | P23467 | 2/20 | 0.51 |
| ▸ | PTPRE | P23469 | 2/20 | 0.51 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.51 |
| ▸ | PTPRA | P18433 | 1/20 | 0.51 |
| ▸ | GRIK1 | P39086 | 5/20 | 0.50 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.47 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3915465 | 0.82 | ALDH1A1 (0.61) | ACLYKCNK2KCNK10GRIK1GRIK2 | |
| SCHEMBL29144725 | 0.81 | ALDH1A1 (0.59) | ACLYKCNK2KCNK10GRIK1GRIK2 | |
| SCHEMBL7848210 | 0.80 | GPR35 (0.58) | GPR35PTPN1PTPRCPTPN2PTPRB | |
| SCHEMBL9942872 | 0.79 | ACLY (0.55) | ACLYKCNK2KCNK10GRIK1GRIK2 | |
| SCHEMBL7848417 | 0.79 | PTPN1 (0.56) | GPR35PTPN1KCNK2PTPRCPTPN2 | |
| SCHEMBL7846225 | 0.79 | GRIK1 (0.64) | PTPN1GRIK1KDM4EALDH1A1 | |
| SCHEMBL5145373 | 0.78 | ACLY (0.71) | ACLYGPR35KCNK2KCNK10GRIK1 | |
| SCHEMBL16632333 | 0.78 | ACLY (0.54) | ACLYGPR35KCNK2KCNK10GRIK1 | |
| SCHEMBL4152400 | 0.78 | ACLY (0.54) | ACLYKCNK2KCNK10GRIK1KDM4E | |
| Hydrochloric Acid SCHEMBL145407 | 0.76 | ACLY (0.53) | ACLYGPR35KCNK2KCNK10GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225329-B1 | USEFUL IN THE TREATMENT OF TYPE I DIABETES, TYPE II DIABETES, IMPAIRED GLUCOSE TOLERANCE, INSULIN AUTOIMMUNITY DISEASES WITH DYSFUNCTIONS OF THE COAGULATION SYSTEM, ALLERGIC DISEASES | NOVO NORDISK A/S (DK) | 2001-05-01 | — | — | US | disclosed |
| EP-1080068-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES | Novo Nordisk A/S (DK) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999046237-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | disclosed |