Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.55 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.55 |
| ▸ | TAS1R2 | Q8TE23 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | PYGL | P06737 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TPMT | P51580 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9944206 | 0.92 | TAS1R3 (0.56) | KMT2APKMTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL9944138 | 0.91 | TAS1R3 (0.57) | KMT2APKMTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL9944146 | 0.87 | TAS1R3 (0.54) | KMT2ATAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL1457759 | 0.85 | TAS1R3 (0.64) | KMT2APKMTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL9944098 | 0.85 | PKM (0.60) | KMT2APKMALDH1A1MEN1PYGL | |
| SCHEMBL1459323 | 0.84 | LMNA (0.57) | KMT2APKMTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL9944174 | 0.84 | TAS1R3 (0.59) | KMT2APKMTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL9944136 | 0.84 | TAS1R3 (0.65) | KMT2APKMTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL9944089 | 0.84 | PKM (0.65) | KMT2APKMMEN1HPGDPYGL | |
| SCHEMBL1458655 | 0.82 | KMT2A (0.67) | KMT2APKMTAS1R3TAS1R1TAS1R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447028-B2 | Therapeutic aryl-amido-aryl compounds and their use | KING'S COLLEGE LONDON (GB) | 2016-09-20 | — | — | US | disclosed |
| US-20160039747-A1 | Therapeutic Aryl-Amido-Aryl Compounds and Their Use | KING'S COLLEGE LONDON (GB) | 2016-02-11 | — | — | US | disclosed |
| US-20120149737-A1 | Therapeutic Aryl-Amido-Aryl Compounds and Their Use | KING'S COLLEGE LONDON (GB) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149737-A1 | Therapeutic Aryl-Amido-Aryl Compounds and Their Use | RARA, RARB, RARG | KMT2A 1418/4885PKM 4030/4885TAS1R3 1123/4885 |
| US-20160039747-A1 | Therapeutic Aryl-Amido-Aryl Compounds and Their Use | RARA, RARB, RARG | KMT2A 1418/4885PKM 4030/4885TAS1R3 1123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.