Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.49 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | GAPDH | P04406 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9946138 | 0.82 | ALDH1A1 (0.49) | CYP3A4LMNACACNA1BAPBA1KMT2A | |
| SCHEMBL9946151 | 0.76 | NR3C1 (0.41) | ACHEKMT2AALDH1A1HTTHSD17B10 | |
| SCHEMBL13720739 | 0.76 | CYP3A4 (0.56) | CYP3A4LMNACACNA1BAPBA1ACHE | |
| SCHEMBL249305 | 0.75 | LMNA (0.76) | CYP3A4LMNAACHEKMT2AMEN1 | |
| SCHEMBL17028900 | 0.75 | LMNA (0.76) | CYP3A4LMNAACHEKMT2AMEN1 | |
| SCHEMBL9946130 | 0.74 | KMO (0.49) | KMT2AMEN1ALDH1A1HSD17B10TP53 | |
| SCHEMBL9946141 | 0.74 | GRIA2 (0.34) | CYP3A4ALDH1A1 | |
| SCHEMBL31522974 | 0.73 | CYP3A4 (0.53) | CYP3A4LMNACACNA1BAPBA1ACHE | |
| SCHEMBL1787633 | 0.73 | CYP3A4 (0.53) | CYP3A4LMNAACHEKMT2AMEN1 | |
| SCHEMBL1792243 | 0.72 | KMO (0.54) | CYP3A4LMNAACHEKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | HTR2C, GRK2, GRK3 | CYP3A4 3867/4885LMNA 3453/4885CACNA1B 2515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.