Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.50 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16687460 | 0.84 | PSMB8 (0.45) | HCRTR1HCRTR2SIRT2SIRT1HDAC3 | |
| SCHEMBL9946132 | 0.81 | ALDH1A1 (0.50) | — | |
| SCHEMBL29029431 | 0.79 | HDAC3 (0.56) | HCRTR1HCRTR2HDAC3HDAC1HDAC2 | |
| SCHEMBL17920283 | 0.79 | PRKCI (0.48) | HCRTR1HCRTR2SIRT2SIRT1HDAC3 | |
| SCHEMBL31617847 | 0.76 | HCRTR1 (0.46) | HCRTR1HCRTR2SIRT2SIRT1HDAC3 | |
| SCHEMBL30941433 | 0.76 | HCRTR1 (0.46) | HCRTR1HCRTR2SIRT2SIRT1HDAC3 | |
| SCHEMBL5190565 | 0.75 | KMO (0.47) | HCRTR1HCRTR2SIRT2SIRT1HDAC3 | |
| SCHEMBL1300326 | 0.74 | PRMT5 (0.47) | HCRTR1HCRTR2SIRT2SIRT1HDAC3 | |
| SCHEMBL29895473 | 0.74 | PRMT5 (0.47) | HCRTR1HCRTR2SIRT2SIRT1HDAC3 | |
| SCHEMBL27935844 | 0.74 | BCL2 (0.43) | HCRTR1HCRTR2SIRT2SIRT1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149693-A1 | THERAPEUTIC COMPOUNDS | HTR2C, GRK2, GRK3 | HCRTR1 1021/4885HCRTR2 338/4885SIRT2 2450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.