Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | POLM | Q9NP87 | 1/20 | 0.40 |
| ▸ | POLK | Q9UBT6 | 1/20 | 0.40 |
| ▸ | POLL | Q9UGP5 | 1/20 | 0.40 |
| ▸ | POLH | Q9Y253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9902245 | 0.88 | ALDH1A1 (0.58) | KMT2AALDH1A1KDM4ESMN1; SMN2GLA | |
| SCHEMBL14060909 | 0.81 | KMT2A (0.55) | KMT2ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL14060987 | 0.81 | KMT2A (0.55) | KMT2ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL27261307 | 0.79 | KMT2A (0.50) | KMT2ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL11956262 | 0.77 | PTGS1 (0.57) | — | |
| SCHEMBL21431967 | 0.77 | KMT2A (0.49) | KMT2ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL17717408 | 0.77 | POLB (0.39) | KMT2AALDH1A1KDM4EGLAGAA | |
| SCHEMBL381723 | 0.76 | ALDH1A1 (0.84) | KMT2ANPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL3219473 | 0.76 | ALDH1A1 (0.84) | KMT2ANPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL381035 | 0.76 | ALDH1A1 (0.84) | KMT2ANPC1RAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10188592-B2 | 2-pyrones | MERCK PATENT GMBH (DE) | 2019-01-29 | — | — | US | disclosed |
| US-10188592-B2 | 2-pyrones | MERCK PATENT GMBH (DE) | 2019-01-29 | — | — | US | disclosed |
| EP-2648689-B1 | 2-PYRONES | MERCK PATENT GMBH (DE) | 2017-12-20 | — | — | EP | disclosed |
| EP-2648689-B1 | 2-PYRONES | MERCK PATENT GMBH (DE) | 2017-12-20 | — | — | EP | disclosed |
| US-20170014325-A1 | 2-PYRONES | MERCK PATENT GMBH (DE) | 2017-01-19 | — | — | US | disclosed |
| US-20170014325-A1 | 2-PYRONES | MERCK PATENT GMBH (DE) | 2017-01-19 | — | — | US | disclosed |
| US-20170014325-A1 | 2-PYRONES | MERCK PATENT GMBH (DE) | 2017-01-19 | — | — | US | disclosed |
| US-9499508-B2 | 2-pyrones | MERCK PATENT GMBH (DE) | 2016-11-22 | — | — | US | disclosed |
| US-9499508-B2 | 2-pyrones | MERCK PATENT GMBH (DE) | 2016-11-22 | — | — | US | disclosed |
| US-9499508-B2 | 2-pyrones | MERCK PATENT GMBH (DE) | 2016-11-22 | — | — | US | disclosed |
| US-20130261175-A1 | 2-PYRONES | MERCK PATENT GMBH (DE) | 2013-10-03 | — | — | US | disclosed |
| US-20130261175-A1 | 2-PYRONES | MERCK PATENT GMBH (DE) | 2013-10-03 | — | — | US | disclosed |
| US-20130261175-A1 | 2-PYRONES | MERCK PATENT GMBH (DE) | 2013-10-03 | — | — | US | disclosed |
| WO-2012076109-A2 | 2-PYRONES | MERCK PATENT GMBH (DE) | 2012-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170014325-A1 | 2-PYRONES | PYCR1, CYP17A1, CYP11B2 | KMT2A 3392/4885NPC1 4319/4885RAB9A 4711/4885 |
| US-20130261175-A1 | 2-PYRONES | PYCR1, CYP17A1, CYP11B2 | KMT2A 3392/4885NPC1 4319/4885RAB9A 4711/4885 |
| US-10188592-B2 | 2-pyrones | PYCR1, CYP17A1, CYP11B2 | KMT2A 3392/4885NPC1 4319/4885RAB9A 4711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.