Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | GAA | P10253 | 5/20 | 0.58 |
| ▸ | GLA | P06280 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | BCL9 | O00512 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9947512 | 0.88 | KMT2A (0.48) | ALDH1A1KMT2AKDM4EGAAGLA | |
| SCHEMBL13228832 | 0.78 | BCL9 (0.55) | ALDH1A1KMT2AKDM4EGAAGLA | |
| SCHEMBL17717403 | 0.78 | ALDH1A1 (0.39) | ALDH1A1KMT2AKDM4EGAAGLA | |
| SCHEMBL9947510 | 0.78 | F2RL1 (0.48) | ALDH1A1KMT2AKDM4EGAAGLA | |
| SCHEMBL9901826 | 0.78 | KDM4E (0.54) | ALDH1A1KMT2AKDM4EGAAGLA | |
| SCHEMBL11929858 | 0.76 | ALDH1A1 (0.49) | ALDH1A1KMT2AKDM4EGAAGLA | |
| SCHEMBL17717408 | 0.76 | POLB (0.39) | ALDH1A1KMT2AKDM4EGAAGLA | |
| SCHEMBL10748577 | 0.75 | HPGD (0.53) | ALDH1A1KMT2AKDM4EGAAGLA | |
| SCHEMBL17070964 | 0.75 | ALDH1A1 (0.48) | ALDH1A1KMT2AKDM4EGAAGLA | |
| SCHEMBL145934 | 0.74 | ALDH1A1 (1.00) | ALDH1A1KMT2AKDM4EGAAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10188592-B2 | 2-pyrones | MERCK PATENT GMBH (DE) | 2019-01-29 | — | — | US | disclosed |
| EP-2648689-B1 | 2-PYRONES | MERCK PATENT GMBH (DE) | 2017-12-20 | — | — | EP | disclosed |
| US-20170014325-A1 | 2-PYRONES | MERCK PATENT GMBH (DE) | 2017-01-19 | — | — | US | disclosed |
| US-9499508-B2 | 2-pyrones | MERCK PATENT GMBH (DE) | 2016-11-22 | — | — | US | disclosed |
| EP-2648689-A2 | 2-PYRONES | Merck Patent GmbH (DE) | 2013-10-16 | — | — | EP | disclosed |
| US-20130261175-A1 | 2-PYRONES | MERCK PATENT GMBH (DE) | 2013-10-03 | — | — | US | disclosed |
| WO-2012076109-A2 | 2-PYRONES | MERCK PATENT GMBH (DE) | 2012-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170014325-A1 | 2-PYRONES | PYCR1, CYP17A1, CYP11B2 | ALDH1A1 658/4885KMT2A 3392/4885KDM4E 1753/4885 |
| US-20130261175-A1 | 2-PYRONES | PYCR1, CYP17A1, CYP11B2 | ALDH1A1 658/4885KMT2A 3392/4885KDM4E 1753/4885 |
| US-10188592-B2 | 2-pyrones | PYCR1, CYP17A1, CYP11B2 | ALDH1A1 658/4885KMT2A 3392/4885KDM4E 1753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.