Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tazarotene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA known ✓ | P10276 | 15/20 | 1.00 |
| ▸ | RARB known ✓ | P10826 | 15/20 | 1.00 |
| ▸ | RARG known ✓ | P13631 | 12/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.77 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tazarotene SCHEMBL29512592 | 1.00 | RARA (1.00) | RARARARBRARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL29397163 | 1.00 | RARA (1.00) | RARARARBRARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL5747908 | 1.00 | RARA (1.00) | RARARARBRARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL6101987 | 0.99 | RARA (0.98) | RARARARBRARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL6841186 | 0.95 | RARB (0.90) | RARARARBRARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL995330 | 0.94 | RARB (0.88) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL9333830 | 0.92 | RARB (0.86) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL8037155 | 0.91 | RARA (0.83) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL19560666 | 0.90 | RARA (0.82) | RARARARBRARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL995895 | 0.90 | RARB (0.81) | RARARARBRARGCYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 28302 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260137644-A1 | COMPOSITIONS INCLUDING CAFFEIC ACID PHENETHYL ESTER | XMK THERAPEUTICS INC. (CA) | 2026-05-21 | — | — | US | claimed |
| US-20260137680-A1 | NOVEL COMPOUNDS | SITRYX THERAPEUTICS LTD (GB) | 2026-05-21 | — | — | US | claimed |
| WO-2026104588-A1 | UROLITHIN COMBINATION | AMAZENTIS SA (CH) | 2026-05-21 | — | — | WO | claimed |
| US-20260138973-A1 | SUBSTITUTED PYRIDINES FOR USE IN TREATING OR PREVENTING INFLAMMATORY DISEASES OR DISEASES ASSOCIATED WITH AN UNDESIRABLE IMMUNE RESPONSE | SITRYX THERAPEUTICS LTD (GB) | 2026-05-21 | — | — | US | claimed |
| CN-122057026-A | Pharmaceutical composition for treating multiple myeloma and application thereof | 南京鼓楼医院 | 2026-05-19 | — | — | CN | claimed |
| CN-122036708-A | Nitric oxide donor type tazarotene derivative and preparation method and application thereof | 中国药科大学 | 2026-05-15 | — | — | CN | claimed |
| WO-2025251988-A9 | REAGENT COMBINATION OR KIT FOR CONSTRUCTING EMBRYOID AND USE THEREOF | 广州国家实验室 | 2026-05-15 | — | — | WO | claimed |
| US-20260116861-A1 | ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2026-04-30 | — | — | US | claimed |
| US-20260115115-A1 | TYROTHRICIN FOR USE IN THE TREATMENT OR PROPHYLAXIS OF BODY ODOUR AND PREPARATIONS THEREFOR | LEIBBRAND THOMAS (DE) | 2026-04-30 | — | — | US | claimed |
| US-12600696-B2 | Aromatic compounds | Xeniopro GmbH (DE) | 2026-04-14 | — | — | US | claimed |
| EP-0812184-A1 | NITRIC OXIDE SYNTHASE INHIBITORS | L'OREAL (FR) | 1997-12-17 | — | — | EP | claimed |
| EP-0785782-A1 | DISUBSTITUTED ACETYLENES BEARING HETEROAROMATIC AND HETEROBICYCLIC GROUPS HAVING RETINOID-LIKE ACTIVITY | Allergan (US) | 1997-07-30 | — | — | EP | claimed |
| US-5650279-A | ISOLATED POLYNUCLEOTIDE WHICH SPECIFICALLY BINDS TAZAROTENE INDUCIBLE GENE | ALLERGAN, INC. (US) | 1997-07-22 | — | — | US | claimed |
| US-5602130-A | ORNITHINE DECARBOXYLASE ENZYME INHIBITOR TREATING SKIN DISORDER, INHIBITING CELL HYPERPROLIFERATION | ALLERGAN | 1997-02-11 | — | — | US | claimed |
| WO-1996026711-A1 | NITRIC OXIDE SYNTHASE INHIBITORS | L'OREAL (FR) | 1996-09-06 | — | — | WO | claimed |
| WO-1996011686-A1 | DISUBSTITUTED ACETYLENES BEARING HETEROAROMATIC AND HETEROBICYCLIC GROUPS HAVING RETINOID-LIKE ACTIVITY | ALLERGAN (US) | 1996-04-25 | — | — | WO | claimed |
| EP-0284288-B1 | DISUBSTITUTED ACETYLENES BEARING HETEROAROMATIC AND HETEROBICYCLIC GROUPS HAVING RETINOID LIKE ACTIVITY | ALLERGAN, INC (US) | 1992-05-27 | — | — | EP | claimed |
| US-5089509-A | Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity | ALLERGAN, INC. (US) | 1992-02-18 | — | — | US | claimed |
| WO-1991013080-A1 | PSEUDONUCLEOSIDES AND PSEUDONUCLEOTIDES AND THEIR POLYMERS | GILEAD SCIENCES, INC. (US) | 1991-09-05 | — | — | WO | claimed |
| EP-0284288-A1 | Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity | ALLERGAN, INC (US) | 1988-09-28 | — | — | EP | claimed |