Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tazarotene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA known ✓ | P10276 | 15/20 | 1.00 |
| ▸ | RARB known ✓ | P10826 | 15/20 | 1.00 |
| ▸ | RARG known ✓ | P13631 | 12/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.77 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tazarotene SCHEMBL29397163 | 1.00 | RARA (1.00) | RARARARBRARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL5747908 | 1.00 | RARA (1.00) | RARARARBRARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL3134 | 1.00 | RARA (1.00) | RARARARBRARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL6101987 | 0.99 | RARA (0.98) | RARARARBRARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL6841186 | 0.95 | RARB (0.90) | RARARARBRARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL995330 | 0.94 | RARB (0.88) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL9333830 | 0.92 | RARB (0.86) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL8037155 | 0.91 | RARA (0.83) | RARARARBRARGCYP3A4KMT2A | |
| SCHEMBL19560666 | 0.90 | RARA (0.82) | RARARARBRARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL995895 | 0.90 | RARB (0.81) | RARARARBRARGCYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024174011-A1 | LIPOSOME, METHOD FOR PREPARING A LIPOSOME, INTRANASAL COMPOSITION COMPRISING A LIPOSOME, METHOD FOR PREPARING AN INTRANASAL COMPOSITION, KIT AND USE OF THE COMPOSITION | ROSSI BERGMANN BARTIRA (BR) | 2024-08-29 | — | — | WO | claimed |
| CN-119656062-A | Composition for protecting cells from oxidative and mitochondrial stresses | 努其杜有限公司 | 2025-03-21 | — | — | CN | disclosed |
| CN-112423726-B | Composition for protecting cells from oxidative and mitochondrial stresses | 努其杜有限公司 | 2024-12-27 | — | — | CN | disclosed |
| CN-115444780-B | Personal care compositions with glutathione precursors comprising nicotinamide and amino acids | 联合利华知识产权控股有限公司 | 2024-10-15 | — | — | CN | disclosed |
| WO-2024174011-A1 | LIPOSOME, METHOD FOR PREPARING A LIPOSOME, INTRANASAL COMPOSITION COMPRISING A LIPOSOME, METHOD FOR PREPARING AN INTRANASAL COMPOSITION, KIT AND USE OF THE COMPOSITION | ROSSI BERGMANN BARTIRA (BR) | 2024-08-29 | — | — | WO | disclosed |
| CN-114767562-B | Topical skin lightening additives and compositions with amino acids and nicotinamide compounds | 联合利华知识产权控股有限公司 | 2024-05-10 | — | — | CN | disclosed |
| CN-116546967-A | Natural skin care composition | 轨迹方案IPCO有限责任公司 | 2023-08-04 | — | — | CN | disclosed |
| CN-110139652-B | ROR-gamma modulators | 爱思凯利尔生物科学私人有限责任公司 | 2022-10-11 | — | — | CN | disclosed |
| CN-109562043-B | Personal care compositions comprising fatty acid amide derivatives | 联合利华知识产权控股有限公司 | 2022-04-08 | — | — | CN | disclosed |