Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 2/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1870772 | 0.73 | L3MBTL1 (0.52) | ALDH1A1TSHRL3MBTL1SMN1; SMN2HPGD | |
| SCHEMBL23467921 | 0.72 | ERCC1 (0.56) | ALDH1A1TSHRERCC1FEN1ERCC4 | |
| SCHEMBL6643800 | 0.70 | MEN1 (0.60) | ALDH1A1TSHRSMN1; SMN2KDM4EHPGD | |
| SCHEMBL5511035 | 0.69 | SMN1; SMN2 (0.61) | ALDH1A1TSHRPDE5AABCC1ABCG2 | |
| SCHEMBL985111 | 0.69 | LMNA (0.54) | ALDH1A1TSHRL3MBTL1ABCC1ABCG2 | |
| SCHEMBL2316603 | 0.68 | TSHR (0.59) | ALDH1A1TSHRL3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL21504745 | 0.68 | CYP4F2 (0.61) | ALDH1A1TSHRERCC1FEN1ERCC4 | |
| SCHEMBL25439893 | 0.68 | TSHR (0.64) | ALDH1A1TSHRL3MBTL1PDE5AABCC1 | |
| Biphenyl SCHEMBL28575404 | 0.68 | TSHR (0.86) | ALDH1A1TSHRL3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL2834317 | 0.68 | ALDH1A1 (1.00) | ALDH1A1ERCC1FEN1ERCC4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165334-A1 | Indole/Benzimidazole Compounds as mTOR Kinase Inhibitors | AMGEN INC. (US) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165334-A1 | Indole/Benzimidazole Compounds as mTOR Kinase Inhibitors | MTOR, PIKFYVE, RICTOR | ALDH1A1 4371/4885TSHR 3673/4885ERCC1 3334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.