Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 10/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.65 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31407211 | 0.85 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3CA12CA1 | |
| SCHEMBL21847315 | 0.81 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3CA12CA1 | |
| SCHEMBL18753948 | 0.80 | NOS3 (0.46) | SLC6A2SLC6A4NOS3NOS1POLB | |
| SCHEMBL91395 | 0.79 | CA12 (0.50) | SLC6A2SLC6A4SLC6A3CA12CA1 | |
| SCHEMBL21193706 | 0.78 | CA12 (0.47) | SLC6A2SLC6A4CA12CA1CA2 | |
| SCHEMBL30421834 | 0.78 | POLB (0.51) | SLC6A2SLC6A4POLBMEN1KMT2A | |
| SCHEMBL4483018 | 0.77 | CYP1A2 (0.51) | SLC6A2SLC6A4SLC6A3CA12CA1 | |
| SCHEMBL5179904 | 0.77 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3CA12CA1 | |
| SCHEMBL31119316 | 0.77 | CYP1A2 (0.51) | SLC6A2SLC6A4SLC6A3CA12CA1 | |
| SCHEMBL1770449 | 0.77 | CYP11B1 (0.45) | SLC6A2SLC6A4SLC6A3CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165351-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165351-A1 | QUINAZOLINE DERIVATIVES | AQP1, F12, AQP3 | SLC6A2 756/4885SLC6A4 679/4885SLC6A3 358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.