Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEP1B | Q16820 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | CA4 | P22748 | 3/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA6 | P23280 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952809 | 0.84 | TAAR1 (0.45) | CYP1A2HTR2A | |
| SCHEMBL9952087 | 0.83 | IMPDH2 (0.38) | KMT2ACYP2D6CYP1A2CYP2C9SLC2A1 | |
| SCHEMBL9952136 | 0.78 | MEP1B (0.39) | MEP1BKMT2ACYP1A2SLC2A1CA2 | |
| SCHEMBL9953809 | 0.77 | SLC2A1 (0.37) | MEP1BSLC2A1 | |
| SCHEMBL5271915 | 0.76 | KMT2A (0.44) | KMT2ACYP2D6CYP1A2CYP2C9SLC2A1 | |
| SCHEMBL14742476 | 0.74 | DRD2 (0.32) | KMT2AHTR2A | |
| SCHEMBL31500453 | 0.72 | MAPT (0.35) | KMT2ACYP2D6CYP1A2CA2CA4 | |
| SCHEMBL26927319 | 0.72 | MAPT (0.35) | KMT2ACYP2D6CYP1A2CA2CA4 | |
| SCHEMBL12813099 | 0.71 | KMT2A (0.37) | KMT2ACYP2D6CYP1A2CYP2C9SLC2A1 | |
| SCHEMBL17398600 | 0.71 | MEP1B (0.36) | MEP1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |