Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.30 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 2/20 | 0.30 |
| ▸ | CA2 | P00918 | 2/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952278 | 0.92 | ALDH1A1 (0.38) | LMNAIMPDH2ALDH1A1KDM4EGAA | |
| SCHEMBL9953183 | 0.80 | TAAR1 (0.37) | IMPDH2ALDH1A1KDM4EGAASLC2A1 | |
| SCHEMBL9952087 | 0.77 | IMPDH2 (0.38) | IMPDH2ALDH1A1KDM4EGAASLC2A1 | |
| SCHEMBL9952029 | 0.77 | TAAR1 (0.46) | IMPDH2 | |
| Hydrochloric Acid SCHEMBL9952054 | 0.76 | TAAR1 (0.45) | IMPDH2 | |
| SCHEMBL9952473 | 0.75 | IMPDH2 (0.41) | LMNAIMPDH2ALDH1A1KDM4EGAA | |
| SCHEMBL14742274 | 0.75 | IMPDH2 (0.36) | IMPDH2SLC2A1CA1CA2 | |
| SCHEMBL28712872 | 0.75 | ALDH1A1 (0.44) | LMNAIMPDH2ALDH1A1KDM4EGAA | |
| SCHEMBL9953040 | 0.74 | IMPDH2 (0.45) | LMNAIMPDH2ALDH1A1KDM4EGAA | |
| SCHEMBL9953206 | 0.73 | IMPDH2 (0.34) | IMPDH2ALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |