Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 5/20 | 0.31 |
| ▸ | DRD3 | P35462 | 4/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | HTR5A | P47898 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952656 | 0.83 | IMPDH2 (0.34) | IMPDH2KDM4EALDH1A1GAAPIK3CD | |
| SCHEMBL14742563 | 0.82 | IMPDH2 (0.33) | IMPDH2DRD2DRD3PIK3CDHTR1A | |
| SCHEMBL14742212 | 0.81 | HTR2C (0.33) | IMPDH2PIK3CDHTR1AHTR1DHTR2C | |
| SCHEMBL9952278 | 0.80 | ALDH1A1 (0.38) | IMPDH2KDM4EALDH1A1GAA | |
| SCHEMBL28712872 | 0.76 | ALDH1A1 (0.44) | IMPDH2KDM4EALDH1A1GAA | |
| SCHEMBL9953202 | 0.74 | PIK3CD (0.42) | PIK3CD | |
| SCHEMBL14742475 | 0.73 | CHRNB2 (0.34) | IMPDH2KDM4EALDH1A1DRD2PIK3CD | |
| SCHEMBL9952084 | 0.73 | LMNA (0.38) | IMPDH2KDM4EALDH1A1GAA | |
| SCHEMBL9952863 | 0.73 | MTNR1A (0.38) | IMPDH2KDM4EALDH1A1GAADRD2 | |
| SCHEMBL14742490 | 0.71 | DRD2 (0.32) | DRD2DRD3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |