Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 8/20 | 0.34 |
| ▸ | ICMT | O60725 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953835 | 0.83 | TAAR1 (0.38) | TAAR1 | |
| SCHEMBL9953794 | 0.81 | TAAR1 (0.40) | TAAR1FFAR1FFAR4GRIN2BICMT | |
| SCHEMBL9929704 | 0.80 | DHODH (0.35) | GRIN2BDCLRE1BPTPN11 | |
| SCHEMBL9952395 | 0.79 | PIK3CD (0.36) | GRIN2BICMTPTPN11 | |
| SCHEMBL9953114 | 0.78 | TAAR1 (0.38) | TAAR1FFAR1FFAR4PTGER2 | |
| SCHEMBL9953176 | 0.78 | LMNA (0.39) | TAAR1GRIN2BCYP1A2 | |
| SCHEMBL9953781 | 0.77 | PIK3CD (0.39) | — | |
| SCHEMBL9952729 | 0.75 | PIK3CD (0.44) | TAAR1 | |
| SCHEMBL9928939 | 0.71 | DHODH (0.36) | GRIN2BPTPN11 | |
| SCHEMBL2012666 | 0.71 | TAAR1 (0.47) | TAAR1ICMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |