Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.39 |
| ▸ | FBP1 | P09467 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | MGMT | P16455 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2017946 | 0.84 | LMNA (0.37) | LMNAFBP1MAPTKMT2AMEN1 | |
| SCHEMBL9929067 | 0.78 | PIK3CD (0.37) | LMNAFBP1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL9953794 | 0.78 | TAAR1 (0.40) | TAAR1GRIN2B | |
| SCHEMBL9953835 | 0.78 | TAAR1 (0.38) | TAAR1GRIN1 | |
| SCHEMBL9952399 | 0.78 | TAAR1 (0.38) | TAAR1GRIN2BCYP1A2 | |
| SCHEMBL9952729 | 0.77 | PIK3CD (0.44) | TAAR1KMT2AMEN1 | |
| SCHEMBL2017942 | 0.77 | FBP1 (0.40) | LMNAFBP1MAPTKMT2AMEN1 | |
| SCHEMBL9960500 | 0.77 | PIK3CD (0.40) | MAPTKMT2AMEN1POLBGSK3A | |
| SCHEMBL9953114 | 0.76 | TAAR1 (0.38) | TAAR1MAPTKMT2AMEN1 | |
| SCHEMBL2012666 | 0.73 | TAAR1 (0.47) | TAAR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |