Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.32 |
| ▸ | AR | P10275 | 2/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | ACLY | P53396 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952399 | 0.83 | TAAR1 (0.38) | TAAR1 | |
| SCHEMBL18927066 | 0.79 | BTK (0.41) | PAX8PTGS2NR1H2NR1H3SCN9A | |
| SCHEMBL9928836 | 0.79 | PIK3CD (0.36) | PAX8PTGS2GRIN1 | |
| SCHEMBL9929263 | 0.78 | SCN9A (0.38) | PAX8PTGS2ARSCN9A | |
| SCHEMBL9953176 | 0.78 | LMNA (0.39) | TAAR1GRIN1 | |
| SCHEMBL9953794 | 0.76 | TAAR1 (0.40) | TAAR1 | |
| SCHEMBL9952729 | 0.75 | PIK3CD (0.44) | TAAR1 | |
| SCHEMBL9953114 | 0.74 | TAAR1 (0.38) | TAAR1 | |
| SCHEMBL2012666 | 0.71 | TAAR1 (0.47) | TAAR1 | |
| SCHEMBL9952898 | 0.70 | CYP11B1 (0.37) | TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |