Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.40 |
| ▸ | NPY4R | P50391 | 9/20 | 0.37 |
| ▸ | NPY1R | P25929 | 6/20 | 0.37 |
| ▸ | NPY2R | P49146 | 4/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.37 |
| ▸ | OTC | P00480 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.35 |
| ▸ | RRM1 | P23921 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27382578 | 1.00 | NOS3 (0.41) | NOS3NOS1NOS2DPP7NPY4R | |
| Hydrochloric Acid SCHEMBL8063762 | 0.98 | NOS3 (0.41) | NOS3NOS1NOS2DPP7NPY4R | |
| SCHEMBL475812 | 0.84 | NOS3 (0.38) | NOS3NOS1NOS2DPP7NPY4R | |
| SCHEMBL19644274 | 0.84 | NOS3 (0.38) | NOS3NOS1NOS2DPP7NPY4R | |
| SCHEMBL18796571 | 0.84 | DPP7 (0.41) | NOS3NOS1NOS2DPP7NPY4R | |
| Arginine SCHEMBL27850376 | 0.83 | NOS2 (0.57) | NOS3NOS1NOS2OTCMEN1 | |
| Arginine SCHEMBL27850377 | 0.83 | NOS2 (0.57) | NOS3NOS1NOS2OTCMEN1 | |
| SCHEMBL27484222 | 0.83 | NOS2 (0.43) | NOS3NOS1NOS2DPP7NPY4R | |
| SCHEMBL27484223 | 0.83 | NOS2 (0.43) | NOS3NOS1NOS2DPP7NPY4R | |
| Hydrochloric Acid SCHEMBL18796570 | 0.83 | DPP7 (0.41) | NOS3NOS1NOS2DPP7NPY4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120196933-A1 | MEXILETINE PRODRUGS | FRANKLIN RICHARD (GB) | 2012-08-02 | — | — | US | disclosed |
| WO-2012085586-A1 | MEXILETINE PRODRUGS | SHIRE, LLC (US) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120196933-A1 | MEXILETINE PRODRUGS | SLC16A1, MTPN, SLC16A3 | NOS3 4201/4885NOS1 3389/4885NOS2 3965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.