Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | APP | P05067 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953825 | 0.88 | MAPT (0.48) | KDM4EALDH1A1MAPTCYP1A2CYP3A4 | |
| SCHEMBL9953906 | 0.88 | SMN1; SMN2 (0.44) | KDM4EALDH1A1POLBMAPTRAB9A | |
| SCHEMBL9954417 | 0.87 | SMN1; SMN2 (0.44) | KDM4EALDH1A1POLBMAPTRAB9A | |
| SCHEMBL9954352 | 0.85 | SMN1; SMN2 (0.66) | ALDH1A1MAPTSMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL9953173 | 0.81 | SMN1; SMN2 (0.48) | ALDH1A1POLBMAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL9955390 | 0.80 | MAPT (0.44) | KDM4EALDH1A1MAPTRAB9ATHRB | |
| SCHEMBL9953974 | 0.79 | KLKB1 (0.45) | ALDH1A1MAPTSMN1; SMN2THRBLMNA | |
| SCHEMBL9953751 | 0.76 | KLKB1 (0.45) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9953908 | 0.76 | TP53 (0.47) | KDM4EALDH1A1MAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL9953155 | 0.76 | ATM (0.48) | ALDH1A1MAPTL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |